Afraid of the dark: Light acutely suppresses activity in the human amygdala.

Light improves mood. The amygdala plays a critical role in regulating emotion, including fear-related responses. In rodents the amygdala receives direct light input from the retina, and light may play a role in fear-related learning. A direct effect of light on the amygdala represents a plausible me...

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Autores principales:	Elise M McGlashan, Govinda R Poudel, Sharna D Jamadar, Andrew J K Phillips, Sean W Cain
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b82d8b74cf14ceb8a0eb19f324a9500
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spelling	oai:doaj.org-article:7b82d8b74cf14ceb8a0eb19f324a95002021-12-02T20:03:52ZAfraid of the dark: Light acutely suppresses activity in the human amygdala.1932-620310.1371/journal.pone.0252350https://doaj.org/article/7b82d8b74cf14ceb8a0eb19f324a95002021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252350https://doaj.org/toc/1932-6203Light improves mood. The amygdala plays a critical role in regulating emotion, including fear-related responses. In rodents the amygdala receives direct light input from the retina, and light may play a role in fear-related learning. A direct effect of light on the amygdala represents a plausible mechanism of action for light's mood-elevating effects in humans. However, the effect of light on activity in the amygdala in humans is not well understood. We examined the effect of passive dim-to-moderate white light exposure on activation of the amygdala in healthy young adults using the BOLD fMRI response (3T Siemens scanner; n = 23). Participants were exposed to alternating 30s blocks of light (10 lux or 100 lux) and dark (<1 lux), with each light intensity being presented separately. Light, compared with dark, suppressed activity in the amygdala. Moderate light exposure resulted in greater suppression of amygdala activity than dim light. Furthermore, functional connectivity between the amygdala and ventro-medial prefrontal cortex was enhanced during light relative to dark. These effects may contribute to light's mood-elevating effects, via a reduction in negative, fear-related affect and enhanced processing of negative emotion.Elise M McGlashanGovinda R PoudelSharna D JamadarAndrew J K PhillipsSean W CainPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252350 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elise M McGlashan Govinda R Poudel Sharna D Jamadar Andrew J K Phillips Sean W Cain Afraid of the dark: Light acutely suppresses activity in the human amygdala.
description	Light improves mood. The amygdala plays a critical role in regulating emotion, including fear-related responses. In rodents the amygdala receives direct light input from the retina, and light may play a role in fear-related learning. A direct effect of light on the amygdala represents a plausible mechanism of action for light's mood-elevating effects in humans. However, the effect of light on activity in the amygdala in humans is not well understood. We examined the effect of passive dim-to-moderate white light exposure on activation of the amygdala in healthy young adults using the BOLD fMRI response (3T Siemens scanner; n = 23). Participants were exposed to alternating 30s blocks of light (10 lux or 100 lux) and dark (<1 lux), with each light intensity being presented separately. Light, compared with dark, suppressed activity in the amygdala. Moderate light exposure resulted in greater suppression of amygdala activity than dim light. Furthermore, functional connectivity between the amygdala and ventro-medial prefrontal cortex was enhanced during light relative to dark. These effects may contribute to light's mood-elevating effects, via a reduction in negative, fear-related affect and enhanced processing of negative emotion.
format	article
author	Elise M McGlashan Govinda R Poudel Sharna D Jamadar Andrew J K Phillips Sean W Cain
author_facet	Elise M McGlashan Govinda R Poudel Sharna D Jamadar Andrew J K Phillips Sean W Cain
author_sort	Elise M McGlashan
title	Afraid of the dark: Light acutely suppresses activity in the human amygdala.
title_short	Afraid of the dark: Light acutely suppresses activity in the human amygdala.
title_full	Afraid of the dark: Light acutely suppresses activity in the human amygdala.
title_fullStr	Afraid of the dark: Light acutely suppresses activity in the human amygdala.
title_full_unstemmed	Afraid of the dark: Light acutely suppresses activity in the human amygdala.
title_sort	afraid of the dark: light acutely suppresses activity in the human amygdala.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7b82d8b74cf14ceb8a0eb19f324a9500
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Afraid of the dark: Light acutely suppresses activity in the human amygdala.

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