Organelle Dynamics in Apicomplexan Parasites

ABSTRACT Apicomplexan parasites, such as Toxoplasma gondii and Plasmodium falciparum, are the cause of many important human and animal diseases. While T. gondii tachyzoites replicate through endodyogeny, during which two daughter cells are formed within the parental cell, P. falciparum replicates th...

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Autores principales:	Julie M. J. Verhoef, Markus Meissner, Taco W. A. Kooij
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Plasmodium Toxoplasma organelle segregation mitochondrion dynamins Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7b853ce546c24ffd98c13f7fa108dcc8
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spelling	oai:doaj.org-article:7b853ce546c24ffd98c13f7fa108dcc82021-11-10T18:37:52ZOrganelle Dynamics in Apicomplexan Parasites10.1128/mBio.01409-212150-7511https://doaj.org/article/7b853ce546c24ffd98c13f7fa108dcc82021-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01409-21https://doaj.org/toc/2150-7511ABSTRACT Apicomplexan parasites, such as Toxoplasma gondii and Plasmodium falciparum, are the cause of many important human and animal diseases. While T. gondii tachyzoites replicate through endodyogeny, during which two daughter cells are formed within the parental cell, P. falciparum replicates through schizogony, where up to 32 parasites are formed in a single infected red blood cell and even thousands of daughter cells during mosquito- or liver-stage development. These processes require a tightly orchestrated division and distribution over the daughter parasites of one-per-cell organelles such as the mitochondrion and apicoplast. Although proper organelle segregation is highly essential, the molecular mechanism and the key proteins involved remain largely unknown. In this review, we describe organelle dynamics during cell division in T. gondii and P. falciparum, summarize the current understanding of the molecular mechanisms underlying organelle fission in these parasites, and introduce candidate fission proteins.Julie M. J. VerhoefMarkus MeissnerTaco W. A. KooijAmerican Society for MicrobiologyarticlePlasmodiumToxoplasmaorganelle segregationmitochondriondynaminsMicrobiologyQR1-502ENmBio, Vol 12, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Plasmodium Toxoplasma organelle segregation mitochondrion dynamins Microbiology QR1-502
spellingShingle	Plasmodium Toxoplasma organelle segregation mitochondrion dynamins Microbiology QR1-502 Julie M. J. Verhoef Markus Meissner Taco W. A. Kooij Organelle Dynamics in Apicomplexan Parasites
description	ABSTRACT Apicomplexan parasites, such as Toxoplasma gondii and Plasmodium falciparum, are the cause of many important human and animal diseases. While T. gondii tachyzoites replicate through endodyogeny, during which two daughter cells are formed within the parental cell, P. falciparum replicates through schizogony, where up to 32 parasites are formed in a single infected red blood cell and even thousands of daughter cells during mosquito- or liver-stage development. These processes require a tightly orchestrated division and distribution over the daughter parasites of one-per-cell organelles such as the mitochondrion and apicoplast. Although proper organelle segregation is highly essential, the molecular mechanism and the key proteins involved remain largely unknown. In this review, we describe organelle dynamics during cell division in T. gondii and P. falciparum, summarize the current understanding of the molecular mechanisms underlying organelle fission in these parasites, and introduce candidate fission proteins.
format	article
author	Julie M. J. Verhoef Markus Meissner Taco W. A. Kooij
author_facet	Julie M. J. Verhoef Markus Meissner Taco W. A. Kooij
author_sort	Julie M. J. Verhoef
title	Organelle Dynamics in Apicomplexan Parasites
title_short	Organelle Dynamics in Apicomplexan Parasites
title_full	Organelle Dynamics in Apicomplexan Parasites
title_fullStr	Organelle Dynamics in Apicomplexan Parasites
title_full_unstemmed	Organelle Dynamics in Apicomplexan Parasites
title_sort	organelle dynamics in apicomplexan parasites
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/7b853ce546c24ffd98c13f7fa108dcc8
work_keys_str_mv	AT juliemjverhoef organelledynamicsinapicomplexanparasites AT markusmeissner organelledynamicsinapicomplexanparasites AT tacowakooij organelledynamicsinapicomplexanparasites
_version_	1718439789592576000

Organelle Dynamics in Apicomplexan Parasites

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