HCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate.

HCV is a major etiological agent of liver disease with a high rate of chronic evolution. The virus possesses 6 genotypes with many subtypes. The rate of spontaneous clearance among HCV infected individuals denotes a genetic determinant factor. The current study was designed in order to estimate the...

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Autores principales:	Ahmed S Abdel-Moneim, Mohammad S Bamaga, Gaber M G Shehab, Abdel-Aziz S A Abu-Elsaad, Fayssal M Farahat
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b87a2ad7ea341caa573a810b0b49b09
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spelling	oai:doaj.org-article:7b87a2ad7ea341caa573a810b0b49b092021-11-18T07:30:17ZHCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate.1932-620310.1371/journal.pone.0029781https://doaj.org/article/7b87a2ad7ea341caa573a810b0b49b092012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22253780/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203HCV is a major etiological agent of liver disease with a high rate of chronic evolution. The virus possesses 6 genotypes with many subtypes. The rate of spontaneous clearance among HCV infected individuals denotes a genetic determinant factor. The current study was designed in order to estimate the rate of HCV infection and ratio of virus clearance among a group of infected patients in Saudi Arabia from 2008 to 2011. It was additionally designed to determine the genotypes of the HCV in persistently infected patients. HCV seroprevalence was conducted on a total of 15,323 individuals. Seropositive individuals were tested by Cobas AmpliPrep/Cobas TaqMan HCV assay to determine the ratio of persistently infected patients to those who showed spontaneous viral clearance. HCV genotyping on random samples from persistently infected patients were conducted based on the differences in the 5'untranslated region (5'UTR). Anti-HCV antibodies were detected in 7.3% of the totally examined sera. A high percentage of the HCV infected individuals experienced virus clearance (48.4%). HCV genotyping revealed the presence of genotypes 1 and 4, the latter represented 97.6% of the tested strains. Evidences of the widespread of the HCV genotype 4 and a high rate of HCV virus clearance were found in Saudi Arabia.Ahmed S Abdel-MoneimMohammad S BamagaGaber M G ShehabAbdel-Aziz S A Abu-ElsaadFayssal M FarahatPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29781 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ahmed S Abdel-Moneim Mohammad S Bamaga Gaber M G Shehab Abdel-Aziz S A Abu-Elsaad Fayssal M Farahat HCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate.
description	HCV is a major etiological agent of liver disease with a high rate of chronic evolution. The virus possesses 6 genotypes with many subtypes. The rate of spontaneous clearance among HCV infected individuals denotes a genetic determinant factor. The current study was designed in order to estimate the rate of HCV infection and ratio of virus clearance among a group of infected patients in Saudi Arabia from 2008 to 2011. It was additionally designed to determine the genotypes of the HCV in persistently infected patients. HCV seroprevalence was conducted on a total of 15,323 individuals. Seropositive individuals were tested by Cobas AmpliPrep/Cobas TaqMan HCV assay to determine the ratio of persistently infected patients to those who showed spontaneous viral clearance. HCV genotyping on random samples from persistently infected patients were conducted based on the differences in the 5'untranslated region (5'UTR). Anti-HCV antibodies were detected in 7.3% of the totally examined sera. A high percentage of the HCV infected individuals experienced virus clearance (48.4%). HCV genotyping revealed the presence of genotypes 1 and 4, the latter represented 97.6% of the tested strains. Evidences of the widespread of the HCV genotype 4 and a high rate of HCV virus clearance were found in Saudi Arabia.
format	article
author	Ahmed S Abdel-Moneim Mohammad S Bamaga Gaber M G Shehab Abdel-Aziz S A Abu-Elsaad Fayssal M Farahat
author_facet	Ahmed S Abdel-Moneim Mohammad S Bamaga Gaber M G Shehab Abdel-Aziz S A Abu-Elsaad Fayssal M Farahat
author_sort	Ahmed S Abdel-Moneim
title	HCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate.
title_short	HCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate.
title_full	HCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate.
title_fullStr	HCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate.
title_full_unstemmed	HCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate.
title_sort	hcv infection among saudi population: high prevalence of genotype 4 and increased viral clearance rate.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/7b87a2ad7ea341caa573a810b0b49b09
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HCV infection among Saudi population: high prevalence of genotype 4 and increased viral clearance rate.

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