The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study

Theresa Lichtenberg,1 Simon von Stengel,1 Cornel Sieber,2 Wolfgang Kemmler1 1Osteoporosis Research-Center, Institute of Medical Physics, Faculty of Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany; 2Internal Medicine and Geriatric Medicine, Institute of Biome...

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Autores principales:	Lichtenberg T, von Stengel S, Sieber C, Kemmler W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	hi-rt high-intensity resistance training osteosarcopenia sarcopenia smi community-dwelling older people Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7b87d643436348babee010648134cd51
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spelling	oai:doaj.org-article:7b87d643436348babee010648134cd512021-12-02T10:40:30ZThe Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study1178-1998https://doaj.org/article/7b87d643436348babee010648134cd512019-12-01T00:00:00Zhttps://www.dovepress.com/the-favorable-effects-of-a-high-intensity-resistance-training-on-sarco-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Theresa Lichtenberg,1 Simon von Stengel,1 Cornel Sieber,2 Wolfgang Kemmler1 1Osteoporosis Research-Center, Institute of Medical Physics, Faculty of Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany; 2Internal Medicine and Geriatric Medicine, Institute of Biomedicine of Aging, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, GermanyCorrespondence: Wolfgang Kemmler; Theresa LichtenbergInstitute of Medical Physics, Faculty of Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Henkestrasse 91, 91052, Erlangen, GermanyTel +49 9131 8523999Fax +49 9131 8522824Email wolfgang.kemmler@imp.uni-erlangen.de; theresa.lichtenberg@gmail.comPurpose: Sarcopenia, the loss of muscle mass combined with the loss of muscle function, has become a public health issue. There is an urgent need for interventions. The study aimed to determine the effect of high-intensity resistance training (HI-RT), a time- and cost-efficient training modality, on sarcopenia in osteosarcopenic (OS) older men.Methods: Forty-three community-dwelling men aged ≥72 years from Northern Bavaria, Germany, with OS were randomly assigned to either an active HI-RT group (HI-RT) or an inactive control group (CG). Both received dietary protein (up to 1.5 g/kg/day in HI-RT and 1.2 g/kg/day in CG) and Vitamin-D (up to 800 IE/d) supplements. The HI-RT was applied as a consistently supervised single-set training on resistance exercise machines using intensifying strategies, with two training sessions/week, structured into three phases (ranging from 8 to 12 weeks) totaling 28 weeks. The primary study endpoint was the Sarcopenia Z-score; secondary endpoints were changes in the underlying physiological parameters, skeletal muscle mass index (SMI), handgrip-strength and gait velocity.Results: The results show a significant effect of the exercise intervention on the sarcopenia Z-score in the HI-RT (p<0.001) and a significant worsening of it in the CG (p=0.012) in the intention-to-treat analysis, as well as a significant intergroup change (p<0.001). Analysis upon the underlying parameters showed a significant increase of skeletal muscle mass index (SMI) in the HI-RT group (p<0.001) and a significant intergroup difference of SMI (p<0.001) and handgrip strength (p<0.001). There were no adverse effects related to dietary supplementation or training.Conclusion: The results clearly confirm the favorable effects of HI-RT on sarcopenia. We conclude that HI-RT is a feasible, highly efficient and safe training modality for combating sarcopenia, also in the elderly.Keywords: HI-RT, high-intensity resistance training, osteosarcopenia, sarcopenia, SMI, community-dwelling, older peopleLichtenberg Tvon Stengel SSieber CKemmler WDove Medical Pressarticlehi-rthigh-intensity resistance trainingosteosarcopeniasarcopeniasmicommunity-dwellingolder peopleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 2173-2186 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	hi-rt high-intensity resistance training osteosarcopenia sarcopenia smi community-dwelling older people Geriatrics RC952-954.6
spellingShingle	hi-rt high-intensity resistance training osteosarcopenia sarcopenia smi community-dwelling older people Geriatrics RC952-954.6 Lichtenberg T von Stengel S Sieber C Kemmler W The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study
description	Theresa Lichtenberg,1 Simon von Stengel,1 Cornel Sieber,2 Wolfgang Kemmler1 1Osteoporosis Research-Center, Institute of Medical Physics, Faculty of Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany; 2Internal Medicine and Geriatric Medicine, Institute of Biomedicine of Aging, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, GermanyCorrespondence: Wolfgang Kemmler; Theresa LichtenbergInstitute of Medical Physics, Faculty of Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Henkestrasse 91, 91052, Erlangen, GermanyTel +49 9131 8523999Fax +49 9131 8522824Email wolfgang.kemmler@imp.uni-erlangen.de; theresa.lichtenberg@gmail.comPurpose: Sarcopenia, the loss of muscle mass combined with the loss of muscle function, has become a public health issue. There is an urgent need for interventions. The study aimed to determine the effect of high-intensity resistance training (HI-RT), a time- and cost-efficient training modality, on sarcopenia in osteosarcopenic (OS) older men.Methods: Forty-three community-dwelling men aged ≥72 years from Northern Bavaria, Germany, with OS were randomly assigned to either an active HI-RT group (HI-RT) or an inactive control group (CG). Both received dietary protein (up to 1.5 g/kg/day in HI-RT and 1.2 g/kg/day in CG) and Vitamin-D (up to 800 IE/d) supplements. The HI-RT was applied as a consistently supervised single-set training on resistance exercise machines using intensifying strategies, with two training sessions/week, structured into three phases (ranging from 8 to 12 weeks) totaling 28 weeks. The primary study endpoint was the Sarcopenia Z-score; secondary endpoints were changes in the underlying physiological parameters, skeletal muscle mass index (SMI), handgrip-strength and gait velocity.Results: The results show a significant effect of the exercise intervention on the sarcopenia Z-score in the HI-RT (p<0.001) and a significant worsening of it in the CG (p=0.012) in the intention-to-treat analysis, as well as a significant intergroup change (p<0.001). Analysis upon the underlying parameters showed a significant increase of skeletal muscle mass index (SMI) in the HI-RT group (p<0.001) and a significant intergroup difference of SMI (p<0.001) and handgrip strength (p<0.001). There were no adverse effects related to dietary supplementation or training.Conclusion: The results clearly confirm the favorable effects of HI-RT on sarcopenia. We conclude that HI-RT is a feasible, highly efficient and safe training modality for combating sarcopenia, also in the elderly.Keywords: HI-RT, high-intensity resistance training, osteosarcopenia, sarcopenia, SMI, community-dwelling, older people
format	article
author	Lichtenberg T von Stengel S Sieber C Kemmler W
author_facet	Lichtenberg T von Stengel S Sieber C Kemmler W
author_sort	Lichtenberg T
title	The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study
title_short	The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study
title_full	The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study
title_fullStr	The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study
title_full_unstemmed	The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study
title_sort	favorable effects of a high-intensity resistance training on sarcopenia in older community-dwelling men with osteosarcopenia: the randomized controlled frost study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7b87d643436348babee010648134cd51
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The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study

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