MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

Chemotherapy resistance in recurrent gliomas is a large hurdle for successful therapy. Here, the authors show that some recurrent gliomas harbour O-6-methylguanine-DNA methyltransferase (MGMT) genomic rearrangements, and in vitro and in vivo these contribute to temozolomide resistance.

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Autores principales:	Barbara Oldrini, Nuria Vaquero-Siguero, Quanhua Mu, Paula Kroon, Ying Zhang, Marcos Galán-Ganga, Zhaoshi Bao, Zheng Wang, Hanjie Liu, Jason K. Sa, Junfei Zhao, Hoon Kim, Sandra Rodriguez-Perales, Do-Hyun Nam, Roel G. W. Verhaak, Raul Rabadan, Tao Jiang, Jiguang Wang, Massimo Squatrito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b8914f315a045a59cf1cda9e3456735
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spelling	oai:doaj.org-article:7b8914f315a045a59cf1cda9e34567352021-12-02T18:49:31ZMGMT genomic rearrangements contribute to chemotherapy resistance in gliomas10.1038/s41467-020-17717-02041-1723https://doaj.org/article/7b8914f315a045a59cf1cda9e34567352020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17717-0https://doaj.org/toc/2041-1723Chemotherapy resistance in recurrent gliomas is a large hurdle for successful therapy. Here, the authors show that some recurrent gliomas harbour O-6-methylguanine-DNA methyltransferase (MGMT) genomic rearrangements, and in vitro and in vivo these contribute to temozolomide resistance.Barbara OldriniNuria Vaquero-SigueroQuanhua MuPaula KroonYing ZhangMarcos Galán-GangaZhaoshi BaoZheng WangHanjie LiuJason K. SaJunfei ZhaoHoon KimSandra Rodriguez-PeralesDo-Hyun NamRoel G. W. VerhaakRaul RabadanTao JiangJiguang WangMassimo SquatritoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Barbara Oldrini Nuria Vaquero-Siguero Quanhua Mu Paula Kroon Ying Zhang Marcos Galán-Ganga Zhaoshi Bao Zheng Wang Hanjie Liu Jason K. Sa Junfei Zhao Hoon Kim Sandra Rodriguez-Perales Do-Hyun Nam Roel G. W. Verhaak Raul Rabadan Tao Jiang Jiguang Wang Massimo Squatrito MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas
description	Chemotherapy resistance in recurrent gliomas is a large hurdle for successful therapy. Here, the authors show that some recurrent gliomas harbour O-6-methylguanine-DNA methyltransferase (MGMT) genomic rearrangements, and in vitro and in vivo these contribute to temozolomide resistance.
format	article
author	Barbara Oldrini Nuria Vaquero-Siguero Quanhua Mu Paula Kroon Ying Zhang Marcos Galán-Ganga Zhaoshi Bao Zheng Wang Hanjie Liu Jason K. Sa Junfei Zhao Hoon Kim Sandra Rodriguez-Perales Do-Hyun Nam Roel G. W. Verhaak Raul Rabadan Tao Jiang Jiguang Wang Massimo Squatrito
author_facet	Barbara Oldrini Nuria Vaquero-Siguero Quanhua Mu Paula Kroon Ying Zhang Marcos Galán-Ganga Zhaoshi Bao Zheng Wang Hanjie Liu Jason K. Sa Junfei Zhao Hoon Kim Sandra Rodriguez-Perales Do-Hyun Nam Roel G. W. Verhaak Raul Rabadan Tao Jiang Jiguang Wang Massimo Squatrito
author_sort	Barbara Oldrini
title	MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas
title_short	MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas
title_full	MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas
title_fullStr	MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas
title_full_unstemmed	MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas
title_sort	mgmt genomic rearrangements contribute to chemotherapy resistance in gliomas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7b8914f315a045a59cf1cda9e3456735
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MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

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