Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica

Type I IFN has apposing effects in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Here the authors perform molecular profiling of NMOSD patients and mouse mechanistic experiments of neuro-inflammation to show that IFN-I stimulates pathogenic Th17 via IL-6 production by B...

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Autores principales:	Agnieshka M. Agasing, Qi Wu, Bhuwan Khatri, Nadja Borisow, Klemens Ruprecht, Alexander Ulrich Brandt, Saurabh Gawde, Gaurav Kumar, James L. Quinn, Rose M. Ko, Yang Mao-Draayer, Christopher J. Lessard, Friedemann Paul, Robert C. Axtell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b8aeab093224a3480c864d3e07e1bf6
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spelling	oai:doaj.org-article:7b8aeab093224a3480c864d3e07e1bf62021-12-02T15:56:47ZTranscriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica10.1038/s41467-020-16625-72041-1723https://doaj.org/article/7b8aeab093224a3480c864d3e07e1bf62020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16625-7https://doaj.org/toc/2041-1723Type I IFN has apposing effects in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Here the authors perform molecular profiling of NMOSD patients and mouse mechanistic experiments of neuro-inflammation to show that IFN-I stimulates pathogenic Th17 via IL-6 production by B cells.Agnieshka M. AgasingQi WuBhuwan KhatriNadja BorisowKlemens RuprechtAlexander Ulrich BrandtSaurabh GawdeGaurav KumarJames L. QuinnRose M. KoYang Mao-DraayerChristopher J. LessardFriedemann PaulRobert C. AxtellNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Agnieshka M. Agasing Qi Wu Bhuwan Khatri Nadja Borisow Klemens Ruprecht Alexander Ulrich Brandt Saurabh Gawde Gaurav Kumar James L. Quinn Rose M. Ko Yang Mao-Draayer Christopher J. Lessard Friedemann Paul Robert C. Axtell Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica
description	Type I IFN has apposing effects in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Here the authors perform molecular profiling of NMOSD patients and mouse mechanistic experiments of neuro-inflammation to show that IFN-I stimulates pathogenic Th17 via IL-6 production by B cells.
format	article
author	Agnieshka M. Agasing Qi Wu Bhuwan Khatri Nadja Borisow Klemens Ruprecht Alexander Ulrich Brandt Saurabh Gawde Gaurav Kumar James L. Quinn Rose M. Ko Yang Mao-Draayer Christopher J. Lessard Friedemann Paul Robert C. Axtell
author_facet	Agnieshka M. Agasing Qi Wu Bhuwan Khatri Nadja Borisow Klemens Ruprecht Alexander Ulrich Brandt Saurabh Gawde Gaurav Kumar James L. Quinn Rose M. Ko Yang Mao-Draayer Christopher J. Lessard Friedemann Paul Robert C. Axtell
author_sort	Agnieshka M. Agasing
title	Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica
title_short	Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica
title_full	Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica
title_fullStr	Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica
title_full_unstemmed	Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica
title_sort	transcriptomics and proteomics reveal a cooperation between interferon and t-helper 17 cells in neuromyelitis optica
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7b8aeab093224a3480c864d3e07e1bf6
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Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica

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