Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply

Lipoprotein lipase (LPL) hydrolyzes triglycerides to supply free fatty acids (FFAs) to muscle for energy and adipocytes for storage. Here, the authors demonstrate that Lpl and its product, the FFA docosahexaenoic acid (DHA) are required for haematopoietic stem progenitor cell expansion during zebraf...

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Autores principales:	Chao Liu, Tianxu Han, David L. Stachura, Huawei Wang, Boris L. Vaisman, Jungsu Kim, Richard L. Klemke, Alan T. Remaley, Tariq M. Rana, David Traver, Yury I. Miller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b8b171e2a974a31aa37f80a6f9e12b7
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spelling	oai:doaj.org-article:7b8b171e2a974a31aa37f80a6f9e12b72021-12-02T15:33:58ZLipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply10.1038/s41467-018-03775-y2041-1723https://doaj.org/article/7b8b171e2a974a31aa37f80a6f9e12b72018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03775-yhttps://doaj.org/toc/2041-1723Lipoprotein lipase (LPL) hydrolyzes triglycerides to supply free fatty acids (FFAs) to muscle for energy and adipocytes for storage. Here, the authors demonstrate that Lpl and its product, the FFA docosahexaenoic acid (DHA) are required for haematopoietic stem progenitor cell expansion during zebrafish embryogenesis.Chao LiuTianxu HanDavid L. StachuraHuawei WangBoris L. VaismanJungsu KimRichard L. KlemkeAlan T. RemaleyTariq M. RanaDavid TraverYury I. MillerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Liu Tianxu Han David L. Stachura Huawei Wang Boris L. Vaisman Jungsu Kim Richard L. Klemke Alan T. Remaley Tariq M. Rana David Traver Yury I. Miller Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
description	Lipoprotein lipase (LPL) hydrolyzes triglycerides to supply free fatty acids (FFAs) to muscle for energy and adipocytes for storage. Here, the authors demonstrate that Lpl and its product, the FFA docosahexaenoic acid (DHA) are required for haematopoietic stem progenitor cell expansion during zebrafish embryogenesis.
format	article
author	Chao Liu Tianxu Han David L. Stachura Huawei Wang Boris L. Vaisman Jungsu Kim Richard L. Klemke Alan T. Remaley Tariq M. Rana David Traver Yury I. Miller
author_facet	Chao Liu Tianxu Han David L. Stachura Huawei Wang Boris L. Vaisman Jungsu Kim Richard L. Klemke Alan T. Remaley Tariq M. Rana David Traver Yury I. Miller
author_sort	Chao Liu
title	Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
title_short	Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
title_full	Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
title_fullStr	Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
title_full_unstemmed	Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
title_sort	lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through dha supply
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7b8b171e2a974a31aa37f80a6f9e12b7
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Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply

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