Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study

Background: Both salicylic acid (SA) and trichloroacetic acid (TCA) have proven efficacy with good safety profiles in the treatment of acne vulgaris. Objectives: This study compared the clinical efficacy and safety of 25% TCA and 30% SA peels in the treatment of mild and moderate acne vulgaris....

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Autores principales:	Surabhi Dayal, Satbir Singh, Priyadarshini Sahu
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2021
Materias:	Acne vulgaris trichloroacetic acid salicylic acid Michaelsson acne scores Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/7b8b5254becd4f94a80c6fe562bdc4da
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spelling	oai:doaj.org-article:7b8b5254becd4f94a80c6fe562bdc4da2021-11-17T08:27:51ZEfficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study10.5826/dpc.1103a632160-9381https://doaj.org/article/7b8b5254becd4f94a80c6fe562bdc4da2021-05-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1609https://doaj.org/toc/2160-9381 Background: Both salicylic acid (SA) and trichloroacetic acid (TCA) have proven efficacy with good safety profiles in the treatment of acne vulgaris. Objectives: This study compared the clinical efficacy and safety of 25% TCA and 30% SA peels in the treatment of mild and moderate acne vulgaris. Methods: Patients with mild or moderate acne vulgaris were randomized into 2 groups of 25 persons each, and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Evaluation of active acne was done by individual lesion counts (comedones, papules and pustules) and calculation of the Michaelsson acne score (MAS). Results: Both peels led to significant decrease in individual lesion counts and MAS compared to baseline values, without significant differences between the treatment groups. Thus, the peels had equivalent efficacy against acne vulgaris. The TCA peel was better in treating non-inflammatory lesions, while the SA peel was better for inflammatory lesions, but the differences were not significant. No serious adverse effects were recorded, but more patients in the TCA peel group experienced burning and stinging sensations. Conclusion: The efficacy of 25% TCA is comparable to that of 30% SA in mild-to-moderate acne vulgaris, but safety and tolerability were better with the SA peel than TCA peel. Surabhi DayalSatbir SinghPriyadarshini SahuMattioli1885articleAcne vulgaristrichloroacetic acidsalicylic acidMichaelsson acne scoresDermatologyRL1-803ENDermatology Practical & Conceptual (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acne vulgaris trichloroacetic acid salicylic acid Michaelsson acne scores Dermatology RL1-803
spellingShingle	Acne vulgaris trichloroacetic acid salicylic acid Michaelsson acne scores Dermatology RL1-803 Surabhi Dayal Satbir Singh Priyadarshini Sahu Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study
description	Background: Both salicylic acid (SA) and trichloroacetic acid (TCA) have proven efficacy with good safety profiles in the treatment of acne vulgaris. Objectives: This study compared the clinical efficacy and safety of 25% TCA and 30% SA peels in the treatment of mild and moderate acne vulgaris. Methods: Patients with mild or moderate acne vulgaris were randomized into 2 groups of 25 persons each, and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Evaluation of active acne was done by individual lesion counts (comedones, papules and pustules) and calculation of the Michaelsson acne score (MAS). Results: Both peels led to significant decrease in individual lesion counts and MAS compared to baseline values, without significant differences between the treatment groups. Thus, the peels had equivalent efficacy against acne vulgaris. The TCA peel was better in treating non-inflammatory lesions, while the SA peel was better for inflammatory lesions, but the differences were not significant. No serious adverse effects were recorded, but more patients in the TCA peel group experienced burning and stinging sensations. Conclusion: The efficacy of 25% TCA is comparable to that of 30% SA in mild-to-moderate acne vulgaris, but safety and tolerability were better with the SA peel than TCA peel.
format	article
author	Surabhi Dayal Satbir Singh Priyadarshini Sahu
author_facet	Surabhi Dayal Satbir Singh Priyadarshini Sahu
author_sort	Surabhi Dayal
title	Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study
title_short	Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study
title_full	Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study
title_fullStr	Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study
title_full_unstemmed	Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study
title_sort	efficacy and safety of 25% trichloroacetic acid peel versus 30% salicylic acid peel in mild-to-moderate acne vulgaris: a comparative study
publisher	Mattioli1885
publishDate	2021
url	https://doaj.org/article/7b8b5254becd4f94a80c6fe562bdc4da
work_keys_str_mv	AT surabhidayal efficacyandsafetyof25trichloroaceticacidpeelversus30salicylicacidpeelinmildtomoderateacnevulgarisacomparativestudy AT satbirsingh efficacyandsafetyof25trichloroaceticacidpeelversus30salicylicacidpeelinmildtomoderateacnevulgarisacomparativestudy AT priyadarshinisahu efficacyandsafetyof25trichloroaceticacidpeelversus30salicylicacidpeelinmildtomoderateacnevulgarisacomparativestudy
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Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study

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