The Role of Whole Exome Sequencing in Distinguishing Primary and Secondary Lung Cancers

Natalie I Vokes,1,2 Jianjun Zhang1,2 1Department of Thoracic and Head and Neck Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Natalie I Vokes; Jianjun Zhang Ema...

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Autores principales:	Vokes NI, Zhang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	genomics non-small cell lung cancer metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7b8d0bd9bb5d4aa68d1792fd8d759974
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spelling	oai:doaj.org-article:7b8d0bd9bb5d4aa68d1792fd8d7599742021-12-02T19:17:36ZThe Role of Whole Exome Sequencing in Distinguishing Primary and Secondary Lung Cancers1179-2728https://doaj.org/article/7b8d0bd9bb5d4aa68d1792fd8d7599742021-12-01T00:00:00Zhttps://www.dovepress.com/the-role-of-whole-exome-sequencing-in-distinguishing-primary-and-secon-peer-reviewed-fulltext-article-LCTThttps://doaj.org/toc/1179-2728Natalie I Vokes,1,2 Jianjun Zhang1,2 1Department of Thoracic and Head and Neck Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Natalie I Vokes; Jianjun Zhang Email nvokes@mdanderson.org; jzhang20@mdanderson.orgAbstract: Non-small cell lung cancer (NSCLC) that presents with multiple lung tumors (MLTs) poses a challenge to accurate staging and prognosis. MLTs that arise as clonally related secondary metastases from a common primary are higher stage and often require adjuvant chemotherapy or may in fact be incurable stage IV lesions. Conversely, MLTs that represent distinct primaries have a better prognosis and may be overtreated if inappropriately classified as related secondaries. Historically, pathologic and radiographic criteria were used to distinguish between primary and secondary MLTs; however, the advent of genomic profiling has demonstrated limitations to these historic classification systems. In this review, we discuss the use of molecular profiling to distinguish between primary and secondary lung cancers, with a focus on the insights gleaned from whole exome sequencing (WES) analyses. While WES is not yet feasible in routine clinical practice, WES studies have helped elucidate the clonal relationship between primary and secondary lung cancers and provide important context for the application of targeted sequencing panel-based analyses.Keywords: genomics, non-small cell lung cancer, metastasisVokes NIZhang JDove Medical Pressarticlegenomicsnon-small cell lung cancermetastasisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol Volume 12, Pp 139-149 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	genomics non-small cell lung cancer metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	genomics non-small cell lung cancer metastasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Vokes NI Zhang J The Role of Whole Exome Sequencing in Distinguishing Primary and Secondary Lung Cancers
description	Natalie I Vokes,1,2 Jianjun Zhang1,2 1Department of Thoracic and Head and Neck Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Natalie I Vokes; Jianjun Zhang Email nvokes@mdanderson.org; jzhang20@mdanderson.orgAbstract: Non-small cell lung cancer (NSCLC) that presents with multiple lung tumors (MLTs) poses a challenge to accurate staging and prognosis. MLTs that arise as clonally related secondary metastases from a common primary are higher stage and often require adjuvant chemotherapy or may in fact be incurable stage IV lesions. Conversely, MLTs that represent distinct primaries have a better prognosis and may be overtreated if inappropriately classified as related secondaries. Historically, pathologic and radiographic criteria were used to distinguish between primary and secondary MLTs; however, the advent of genomic profiling has demonstrated limitations to these historic classification systems. In this review, we discuss the use of molecular profiling to distinguish between primary and secondary lung cancers, with a focus on the insights gleaned from whole exome sequencing (WES) analyses. While WES is not yet feasible in routine clinical practice, WES studies have helped elucidate the clonal relationship between primary and secondary lung cancers and provide important context for the application of targeted sequencing panel-based analyses.Keywords: genomics, non-small cell lung cancer, metastasis
format	article
author	Vokes NI Zhang J
author_facet	Vokes NI Zhang J
author_sort	Vokes NI
title	The Role of Whole Exome Sequencing in Distinguishing Primary and Secondary Lung Cancers
title_short	The Role of Whole Exome Sequencing in Distinguishing Primary and Secondary Lung Cancers
title_full	The Role of Whole Exome Sequencing in Distinguishing Primary and Secondary Lung Cancers
title_fullStr	The Role of Whole Exome Sequencing in Distinguishing Primary and Secondary Lung Cancers
title_full_unstemmed	The Role of Whole Exome Sequencing in Distinguishing Primary and Secondary Lung Cancers
title_sort	role of whole exome sequencing in distinguishing primary and secondary lung cancers
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7b8d0bd9bb5d4aa68d1792fd8d759974
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The Role of Whole Exome Sequencing in Distinguishing Primary and Secondary Lung Cancers

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