Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals

Mohammad Farazuddin,1 Bhavyata Dua,2 Qamar Zia,1 Aijaz Ahmad Khan,3 Beenu Joshi,2 Mohammad Owais1 1Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 2Immunology Division, National JALMA Institute for Leprosy and Other Mycobacterial Diseases (NJIL), Agra, 3Department of Anato...

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Autores principales:	Farazuddin M, Dua B, Zia Q, Khan AA, Joshi B, Owais M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7b92950f2ca34dd2a08f65ee55714920
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spelling	oai:doaj.org-article:7b92950f2ca34dd2a08f65ee557149202021-12-02T07:15:35ZChemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals1178-2013https://doaj.org/article/7b92950f2ca34dd2a08f65ee557149202014-03-01T00:00:00Zhttp://www.dovepress.com/chemotherapeutic-potential-of-curcumin-bearing-microcells-against-hepa-a15993https://doaj.org/toc/1178-2013 Mohammad Farazuddin,1 Bhavyata Dua,2 Qamar Zia,1 Aijaz Ahmad Khan,3 Beenu Joshi,2 Mohammad Owais1 1Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 2Immunology Division, National JALMA Institute for Leprosy and Other Mycobacterial Diseases (NJIL), Agra, 3Department of Anatomy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India Abstract: Curcumin (diferuloylmethane) is found in large quantities in the roots of Curcuma longa. It possesses strong antioxidant and anti-inflammatory properties, and inhibits chemically-induced carcinogenesis in the skin, forestomach, colon, and liver. Unfortunately, the poor bioavailability and hydrophobicity of curcumin pose a major hurdle to its use as a potent anticancer agent. To circumvent some of these problems, we developed a novel, dual-core microcell formulation of curcumin. The encapsulation of curcumin in microcells increases its solubility and bioavailability, and facilitates slow release kinetics over extended periods. Besides being safe, these formulations do not bear any toxicity constraints, as revealed by in vitro and in vivo studies. Histopathological analysis revealed that curcumin-bearing microcells helped in regression of hepatocellular carcinoma and the maintenance of cellular architecture in liver tissue. Free curcumin had a very mild effect on cancer suppression. Empty (sham) microcells and microparticles failed to inhibit cancer cells. The novel curcumin formulation was found to suppress hepatocellular carcinoma efficiently in Swiss albino mice. Keywords: diferuloylmethane, carcinogenesis, microparticle, nanocells, cancer, Curcuma longaFarazuddin MDua BZia QKhan AAJoshi BOwais MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1139-1152 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Farazuddin M Dua B Zia Q Khan AA Joshi B Owais M Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals
description	Mohammad Farazuddin,1 Bhavyata Dua,2 Qamar Zia,1 Aijaz Ahmad Khan,3 Beenu Joshi,2 Mohammad Owais1 1Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 2Immunology Division, National JALMA Institute for Leprosy and Other Mycobacterial Diseases (NJIL), Agra, 3Department of Anatomy, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India Abstract: Curcumin (diferuloylmethane) is found in large quantities in the roots of Curcuma longa. It possesses strong antioxidant and anti-inflammatory properties, and inhibits chemically-induced carcinogenesis in the skin, forestomach, colon, and liver. Unfortunately, the poor bioavailability and hydrophobicity of curcumin pose a major hurdle to its use as a potent anticancer agent. To circumvent some of these problems, we developed a novel, dual-core microcell formulation of curcumin. The encapsulation of curcumin in microcells increases its solubility and bioavailability, and facilitates slow release kinetics over extended periods. Besides being safe, these formulations do not bear any toxicity constraints, as revealed by in vitro and in vivo studies. Histopathological analysis revealed that curcumin-bearing microcells helped in regression of hepatocellular carcinoma and the maintenance of cellular architecture in liver tissue. Free curcumin had a very mild effect on cancer suppression. Empty (sham) microcells and microparticles failed to inhibit cancer cells. The novel curcumin formulation was found to suppress hepatocellular carcinoma efficiently in Swiss albino mice. Keywords: diferuloylmethane, carcinogenesis, microparticle, nanocells, cancer, Curcuma longa
format	article
author	Farazuddin M Dua B Zia Q Khan AA Joshi B Owais M
author_facet	Farazuddin M Dua B Zia Q Khan AA Joshi B Owais M
author_sort	Farazuddin M
title	Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals
title_short	Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals
title_full	Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals
title_fullStr	Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals
title_full_unstemmed	Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals
title_sort	chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/7b92950f2ca34dd2a08f65ee55714920
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Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals

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