Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma

Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Here, the authors utilize whole exome sequencing to highlight the monoclonal origin and stemness of H-ChC, as well as substantial intratumoral he...

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Autores principales: Anqiang Wang, Liangcai Wu, Jianzhen Lin, Longzhe Han, Jin Bian, Yan Wu, Simon C. Robson, Lai Xue, Yunxia Ge, Xinting Sang, Wenze Wang, Haitao Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/7b93544ece444ad18922d25dcb43d639
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Sumario:Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Here, the authors utilize whole exome sequencing to highlight the monoclonal origin and stemness of H-ChC, as well as substantial intratumoral heterogeneity.