Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma

Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Here, the authors utilize whole exome sequencing to highlight the monoclonal origin and stemness of H-ChC, as well as substantial intratumoral he...

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Autores principales:	Anqiang Wang, Liangcai Wu, Jianzhen Lin, Longzhe Han, Jin Bian, Yan Wu, Simon C. Robson, Lai Xue, Yunxia Ge, Xinting Sang, Wenze Wang, Haitao Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b93544ece444ad18922d25dcb43d639
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spelling	oai:doaj.org-article:7b93544ece444ad18922d25dcb43d6392021-12-02T16:56:42ZWhole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma10.1038/s41467-018-03276-y2041-1723https://doaj.org/article/7b93544ece444ad18922d25dcb43d6392018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03276-yhttps://doaj.org/toc/2041-1723Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Here, the authors utilize whole exome sequencing to highlight the monoclonal origin and stemness of H-ChC, as well as substantial intratumoral heterogeneity.Anqiang WangLiangcai WuJianzhen LinLongzhe HanJin BianYan WuSimon C. RobsonLai XueYunxia GeXinting SangWenze WangHaitao ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anqiang Wang Liangcai Wu Jianzhen Lin Longzhe Han Jin Bian Yan Wu Simon C. Robson Lai Xue Yunxia Ge Xinting Sang Wenze Wang Haitao Zhao Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma
description	Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Here, the authors utilize whole exome sequencing to highlight the monoclonal origin and stemness of H-ChC, as well as substantial intratumoral heterogeneity.
format	article
author	Anqiang Wang Liangcai Wu Jianzhen Lin Longzhe Han Jin Bian Yan Wu Simon C. Robson Lai Xue Yunxia Ge Xinting Sang Wenze Wang Haitao Zhao
author_facet	Anqiang Wang Liangcai Wu Jianzhen Lin Longzhe Han Jin Bian Yan Wu Simon C. Robson Lai Xue Yunxia Ge Xinting Sang Wenze Wang Haitao Zhao
author_sort	Anqiang Wang
title	Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma
title_short	Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma
title_full	Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma
title_fullStr	Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma
title_full_unstemmed	Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma
title_sort	whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7b93544ece444ad18922d25dcb43d639
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Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma

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