An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion

Mitochondrial fusion is crucial for cellular homeostasis but its regulation is still not fully understood. Here the authors report that a cross-talk between ubiquitin protease Ubp2 and ligases Mdm30 and Rsp5 modulates mitofusin Fzo1 levels and fatty acids saturation and thus mitochondrial fusion.

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Autores principales:	Laetitia Cavellini, Julie Meurisse, Justin Findinier, Zoi Erpapazoglou, Naïma Belgareh-Touzé, Allan M. Weissman, Mickael M. Cohen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b9a49a8e7944cb88214534c58a4c738
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spelling	oai:doaj.org-article:7b9a49a8e7944cb88214534c58a4c7382021-12-02T17:06:06ZAn ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion10.1038/ncomms158322041-1723https://doaj.org/article/7b9a49a8e7944cb88214534c58a4c7382017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15832https://doaj.org/toc/2041-1723Mitochondrial fusion is crucial for cellular homeostasis but its regulation is still not fully understood. Here the authors report that a cross-talk between ubiquitin protease Ubp2 and ligases Mdm30 and Rsp5 modulates mitofusin Fzo1 levels and fatty acids saturation and thus mitochondrial fusion.Laetitia CavelliniJulie MeurisseJustin FindinierZoi ErpapazoglouNaïma Belgareh-TouzéAllan M. WeissmanMickael M. CohenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laetitia Cavellini Julie Meurisse Justin Findinier Zoi Erpapazoglou Naïma Belgareh-Touzé Allan M. Weissman Mickael M. Cohen An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion
description	Mitochondrial fusion is crucial for cellular homeostasis but its regulation is still not fully understood. Here the authors report that a cross-talk between ubiquitin protease Ubp2 and ligases Mdm30 and Rsp5 modulates mitofusin Fzo1 levels and fatty acids saturation and thus mitochondrial fusion.
format	article
author	Laetitia Cavellini Julie Meurisse Justin Findinier Zoi Erpapazoglou Naïma Belgareh-Touzé Allan M. Weissman Mickael M. Cohen
author_facet	Laetitia Cavellini Julie Meurisse Justin Findinier Zoi Erpapazoglou Naïma Belgareh-Touzé Allan M. Weissman Mickael M. Cohen
author_sort	Laetitia Cavellini
title	An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion
title_short	An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion
title_full	An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion
title_fullStr	An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion
title_full_unstemmed	An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion
title_sort	ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7b9a49a8e7944cb88214534c58a4c738
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An ubiquitin-dependent balance between mitofusin turnover and fatty acids desaturation regulates mitochondrial fusion

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