FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION

Objective: To determine frequency of elevated serum uric acid levels in patients with coronary artery disease, association of hyperuricemia with severity of coronary artery disease, gender, age, hypertension, and diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Stu...

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Autores principales:	Syed Ahmad Raza, Naveed Anjum, Saeed Bin Ayaz, Kanza Khalid, Muhammad Saleem, Muhammad Javad Yousaf
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	association coronary artery disease diabetes mellitus gensini score hyperuricemia hypertension Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7b9d09f2405440cb9ed2f7c86ee8fca0
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spelling	oai:doaj.org-article:7b9d09f2405440cb9ed2f7c86ee8fca02021-12-02T18:44:47ZFREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION0030-96482411-8842https://doaj.org/article/7b9d09f2405440cb9ed2f7c86ee8fca02021-04-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/6676https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine frequency of elevated serum uric acid levels in patients with coronary artery disease, association of hyperuricemia with severity of coronary artery disease, gender, age, hypertension, and diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Study: Internal Medicine department, Combined Military Hospital Multan, from Nov 2015 to May 2016. Methodology: One hundred and fifty patients with coronary artery disease were selected consecutively and admitted for coronary angiography. Serum uric acid levels were evaluated after eight hours fasting by photometric technique having normal reference range of 3.5-6.7 mg/dL. Coronary angiography was performed and Gensini score computed. To compare mean Gensini score between normouricemic and hyperuricemic population, student’s t-test was applied. Results: A total of 150 study cases (mean age: 54.4 ± 8.5 years), 101 (67.3%) were male while 49 (32.7%) were female. Diabetes mellitus was present in 43 (28.7%) of cases and hypertension was present in 65 (43.3%). Hyperuricemia was noted in 58 (38.7%) of cases. The mean Gensini score in hyperuricemic patients was significantly higher (40.31 ± 14.64) compared to patients with normal serum uric acid levels (25.02 ± 10.94) (p<0.001). The frequency of hyperuricemia was significantly higher in males, patients ≤60 years of age, and patients with diabetes mellitus (p<0.001, p=0.001 and p=0.001). No significant asso-ciation with hypertension was observed (p=0.314). Conclusion: Frequency of 38.7% for hyperuricemia was noted in our study among patients with coronary artery disease. Hyperuricemia was significantly associated with higher Gensini score, male gender, younger age, and diabetes mellitus.Syed Ahmad RazaNaveed AnjumSaeed Bin AyazKanza KhalidMuhammad SaleemMuhammad Javad YousafArmy Medical College Rawalpindiarticleassociationcoronary artery diseasediabetes mellitusgensini scorehyperuricemiahypertensionMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 2, Pp 651-54 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	association coronary artery disease diabetes mellitus gensini score hyperuricemia hypertension Medicine R Medicine (General) R5-920
spellingShingle	association coronary artery disease diabetes mellitus gensini score hyperuricemia hypertension Medicine R Medicine (General) R5-920 Syed Ahmad Raza Naveed Anjum Saeed Bin Ayaz Kanza Khalid Muhammad Saleem Muhammad Javad Yousaf FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION
description	Objective: To determine frequency of elevated serum uric acid levels in patients with coronary artery disease, association of hyperuricemia with severity of coronary artery disease, gender, age, hypertension, and diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Study: Internal Medicine department, Combined Military Hospital Multan, from Nov 2015 to May 2016. Methodology: One hundred and fifty patients with coronary artery disease were selected consecutively and admitted for coronary angiography. Serum uric acid levels were evaluated after eight hours fasting by photometric technique having normal reference range of 3.5-6.7 mg/dL. Coronary angiography was performed and Gensini score computed. To compare mean Gensini score between normouricemic and hyperuricemic population, student’s t-test was applied. Results: A total of 150 study cases (mean age: 54.4 ± 8.5 years), 101 (67.3%) were male while 49 (32.7%) were female. Diabetes mellitus was present in 43 (28.7%) of cases and hypertension was present in 65 (43.3%). Hyperuricemia was noted in 58 (38.7%) of cases. The mean Gensini score in hyperuricemic patients was significantly higher (40.31 ± 14.64) compared to patients with normal serum uric acid levels (25.02 ± 10.94) (p<0.001). The frequency of hyperuricemia was significantly higher in males, patients ≤60 years of age, and patients with diabetes mellitus (p<0.001, p=0.001 and p=0.001). No significant asso-ciation with hypertension was observed (p=0.314). Conclusion: Frequency of 38.7% for hyperuricemia was noted in our study among patients with coronary artery disease. Hyperuricemia was significantly associated with higher Gensini score, male gender, younger age, and diabetes mellitus.
format	article
author	Syed Ahmad Raza Naveed Anjum Saeed Bin Ayaz Kanza Khalid Muhammad Saleem Muhammad Javad Yousaf
author_facet	Syed Ahmad Raza Naveed Anjum Saeed Bin Ayaz Kanza Khalid Muhammad Saleem Muhammad Javad Yousaf
author_sort	Syed Ahmad Raza
title	FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION
title_short	FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION
title_full	FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION
title_fullStr	FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION
title_full_unstemmed	FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION
title_sort	frequency of hyperuricemia in patients with coronary artery disease and its association with disease severity, age, gender, diabetes mellitus, and hypertension
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/7b9d09f2405440cb9ed2f7c86ee8fca0
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FREQUENCY OF HYPERURICEMIA IN PATIENTS WITH CORONARY ARTERY DISEASE AND ITS ASSOCIATION WITH DISEASE SEVERITY, AGE, GENDER, DIABETES MELLITUS, AND HYPERTENSION

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