Feasibility of large-scale population testing for SARS-CoV-2 detection by self-testing at home
Abstract The simplicity and low cost of rapid point-of-care tests greatly facilitate large-scale population testing, which can contribute to controlling the spread of the COVID-19 virus. We evaluated the applicability of a self-testing strategy for SARS-CoV2 in a population-based, cross-sectional st...
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Nature Portfolio
2021
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oai:doaj.org-article:7b9e4027475d423480ce024e071262c02021-12-02T14:35:33ZFeasibility of large-scale population testing for SARS-CoV-2 detection by self-testing at home10.1038/s41598-021-89236-x2045-2322https://doaj.org/article/7b9e4027475d423480ce024e071262c02021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89236-xhttps://doaj.org/toc/2045-2322Abstract The simplicity and low cost of rapid point-of-care tests greatly facilitate large-scale population testing, which can contribute to controlling the spread of the COVID-19 virus. We evaluated the applicability of a self-testing strategy for SARS-CoV2 in a population-based, cross-sectional study in Cantabria, Spain, between April and May 2020. For the self-testing strategy, participants received the necessary material for the self-collection of blood and performance of a rapid antibody test using lateral flow immunoassay at home without the supervision of healthcare personnel. A total of 1,022 participants were enrolled. Most participants correctly performed the COVID-19 self-test the first time (91.3% [95% CI 89.4–92.9]). Only a minority of the participants (0.7%) needed the help of healthcare personnel, while 6.9% required a second kit delivery, for a total valid test result in 96.9% of the participants. Incorrect use of the self-test was not associated with the educational level, age over 65, or housing area. Prevalence of IgG antibodies against SARS-CoV2 for subjects with a valid rapid test result was 3.1% (95% CI 2.2–4.4), similar to the seroprevalence result obtained using a conventional approach carried out by healthcare professionals. In conclusion, COVID-19 self-testing should be considered as a screening tool.Paula IruzubietaTatiana Fernández-LanasLaura RasinesLorena CayonAna Álvarez-CanceloAlvaro Santos-LasoAgustín García-BlancoSoraya Curiel-OlmoJoaquín CabezasReinhard WallmannEmilio FábregaVíctor M. Martínez-TaboadaJosé L. HernándezMarcos López-HoyosJeffrey V. LazarusJavier CrespoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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DOAJ |
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EN |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Paula Iruzubieta Tatiana Fernández-Lanas Laura Rasines Lorena Cayon Ana Álvarez-Cancelo Alvaro Santos-Laso Agustín García-Blanco Soraya Curiel-Olmo Joaquín Cabezas Reinhard Wallmann Emilio Fábrega Víctor M. Martínez-Taboada José L. Hernández Marcos López-Hoyos Jeffrey V. Lazarus Javier Crespo Feasibility of large-scale population testing for SARS-CoV-2 detection by self-testing at home |
| description |
Abstract The simplicity and low cost of rapid point-of-care tests greatly facilitate large-scale population testing, which can contribute to controlling the spread of the COVID-19 virus. We evaluated the applicability of a self-testing strategy for SARS-CoV2 in a population-based, cross-sectional study in Cantabria, Spain, between April and May 2020. For the self-testing strategy, participants received the necessary material for the self-collection of blood and performance of a rapid antibody test using lateral flow immunoassay at home without the supervision of healthcare personnel. A total of 1,022 participants were enrolled. Most participants correctly performed the COVID-19 self-test the first time (91.3% [95% CI 89.4–92.9]). Only a minority of the participants (0.7%) needed the help of healthcare personnel, while 6.9% required a second kit delivery, for a total valid test result in 96.9% of the participants. Incorrect use of the self-test was not associated with the educational level, age over 65, or housing area. Prevalence of IgG antibodies against SARS-CoV2 for subjects with a valid rapid test result was 3.1% (95% CI 2.2–4.4), similar to the seroprevalence result obtained using a conventional approach carried out by healthcare professionals. In conclusion, COVID-19 self-testing should be considered as a screening tool. |
| format |
article |
| author |
Paula Iruzubieta Tatiana Fernández-Lanas Laura Rasines Lorena Cayon Ana Álvarez-Cancelo Alvaro Santos-Laso Agustín García-Blanco Soraya Curiel-Olmo Joaquín Cabezas Reinhard Wallmann Emilio Fábrega Víctor M. Martínez-Taboada José L. Hernández Marcos López-Hoyos Jeffrey V. Lazarus Javier Crespo |
| author_facet |
Paula Iruzubieta Tatiana Fernández-Lanas Laura Rasines Lorena Cayon Ana Álvarez-Cancelo Alvaro Santos-Laso Agustín García-Blanco Soraya Curiel-Olmo Joaquín Cabezas Reinhard Wallmann Emilio Fábrega Víctor M. Martínez-Taboada José L. Hernández Marcos López-Hoyos Jeffrey V. Lazarus Javier Crespo |
| author_sort |
Paula Iruzubieta |
| title |
Feasibility of large-scale population testing for SARS-CoV-2 detection by self-testing at home |
| title_short |
Feasibility of large-scale population testing for SARS-CoV-2 detection by self-testing at home |
| title_full |
Feasibility of large-scale population testing for SARS-CoV-2 detection by self-testing at home |
| title_fullStr |
Feasibility of large-scale population testing for SARS-CoV-2 detection by self-testing at home |
| title_full_unstemmed |
Feasibility of large-scale population testing for SARS-CoV-2 detection by self-testing at home |
| title_sort |
feasibility of large-scale population testing for sars-cov-2 detection by self-testing at home |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7b9e4027475d423480ce024e071262c0 |
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