Unresectable hepatoblastoma: current perspectives

Angela D Trobaugh-Lotrario,1 Rebecka L Meyers,2 Allison F O’Neill,3 James H Feusner4 1Department of Pediatric Hematology and Oncology, Providence Sacred Heart Children’s Hospital, Spokane, WA, 2Primary Children’s Hospital, University of Utah, Salt Lake City, UT, 3Dana-F...

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Autores principales:	Trobaugh-Lotrario AD, Meyers RL, O'Neill AF, Feusner JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	hepatoblastoma unresectable pediatric Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/7ba52c9a98f04c86931db689c529d9db
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spelling	oai:doaj.org-article:7ba52c9a98f04c86931db689c529d9db2021-12-02T03:57:23ZUnresectable hepatoblastoma: current perspectives1179-1535https://doaj.org/article/7ba52c9a98f04c86931db689c529d9db2017-02-01T00:00:00Zhttps://www.dovepress.com/unresectable-hepatoblastoma-current-perspectives-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Angela D Trobaugh-Lotrario,1 Rebecka L Meyers,2 Allison F O’Neill,3 James H Feusner4 1Department of Pediatric Hematology and Oncology, Providence Sacred Heart Children’s Hospital, Spokane, WA, 2Primary Children’s Hospital, University of Utah, Salt Lake City, UT, 3Dana-Farber Cancer Institute and Harvard University, Boston, MA, 4Children’s Hospital & Research Center Oakland, Oakland, CA, USA Abstract: Although rare, hepatoblastoma is the most common pediatric liver tumor. Complete resection is a critical component for cure; however, most patients will have tumors that are not resected at diagnosis. For these patients, administration of neoadjuvant chemotherapy renders tumors resectable in most patients. For patients whose tumors remain unresectable after chemotherapy, liver transplantation is indicated (in the absence of active unresectable metastatic disease). In patients whose tumors remain unresectable after conventional chemotherapy, interventional techniques may serve as a promising option to reduce tumor size, decrease systemic toxicity, decrease need for liver transplantation, and increase feasibility of tumor resection. Keywords: hepatoblastoma, unresectable, pediatricTrobaugh-Lotrario ADMeyers RLO'Neill AFFeusner JHDove Medical PressarticlehepatoblastomaunresectablepediatricDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 9, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatoblastoma unresectable pediatric Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	hepatoblastoma unresectable pediatric Diseases of the digestive system. Gastroenterology RC799-869 Trobaugh-Lotrario AD Meyers RL O'Neill AF Feusner JH Unresectable hepatoblastoma: current perspectives
description	Angela D Trobaugh-Lotrario,1 Rebecka L Meyers,2 Allison F O’Neill,3 James H Feusner4 1Department of Pediatric Hematology and Oncology, Providence Sacred Heart Children’s Hospital, Spokane, WA, 2Primary Children’s Hospital, University of Utah, Salt Lake City, UT, 3Dana-Farber Cancer Institute and Harvard University, Boston, MA, 4Children’s Hospital & Research Center Oakland, Oakland, CA, USA Abstract: Although rare, hepatoblastoma is the most common pediatric liver tumor. Complete resection is a critical component for cure; however, most patients will have tumors that are not resected at diagnosis. For these patients, administration of neoadjuvant chemotherapy renders tumors resectable in most patients. For patients whose tumors remain unresectable after chemotherapy, liver transplantation is indicated (in the absence of active unresectable metastatic disease). In patients whose tumors remain unresectable after conventional chemotherapy, interventional techniques may serve as a promising option to reduce tumor size, decrease systemic toxicity, decrease need for liver transplantation, and increase feasibility of tumor resection. Keywords: hepatoblastoma, unresectable, pediatric
format	article
author	Trobaugh-Lotrario AD Meyers RL O'Neill AF Feusner JH
author_facet	Trobaugh-Lotrario AD Meyers RL O'Neill AF Feusner JH
author_sort	Trobaugh-Lotrario AD
title	Unresectable hepatoblastoma: current perspectives
title_short	Unresectable hepatoblastoma: current perspectives
title_full	Unresectable hepatoblastoma: current perspectives
title_fullStr	Unresectable hepatoblastoma: current perspectives
title_full_unstemmed	Unresectable hepatoblastoma: current perspectives
title_sort	unresectable hepatoblastoma: current perspectives
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/7ba52c9a98f04c86931db689c529d9db
work_keys_str_mv	AT trobaughlotrarioad unresectablehepatoblastomacurrentperspectives AT meyersrl unresectablehepatoblastomacurrentperspectives AT oneillaf unresectablehepatoblastomacurrentperspectives AT feusnerjh unresectablehepatoblastomacurrentperspectives
_version_	1718401559600037888

Unresectable hepatoblastoma: current perspectives

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