Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance

Schumann et al. demonstrate that the loss of a lactate transporter Slc16a13 increases mitochondrial respiration in the liver, which reduces hepatic lipid accumulation while increasing hepatic insulin sensitivity in mice fed a high-fat diet. This study suggests SLC16A13 as a potential target for the...

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Autores principales:	Tina Schumann, Jörg König, Christian von Loeffelholz, Daniel F. Vatner, Dongyan Zhang, Rachel J. Perry, Michel Bernier, Jason Chami, Christine Henke, Anica Kurzbach, Nermeen N. El-Agroudy, Diana M. Willmes, Dominik Pesta, Rafael de Cabo, John F. O´Sullivan, Eric Simon, Gerald I. Shulman, Bradford S. Hamilton, Andreas L. Birkenfeld
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7ba53b89a38d4e43a575de6ad202ef08
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spelling	oai:doaj.org-article:7ba53b89a38d4e43a575de6ad202ef082021-12-02T14:34:00ZDeletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance10.1038/s42003-021-02279-82399-3642https://doaj.org/article/7ba53b89a38d4e43a575de6ad202ef082021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02279-8https://doaj.org/toc/2399-3642Schumann et al. demonstrate that the loss of a lactate transporter Slc16a13 increases mitochondrial respiration in the liver, which reduces hepatic lipid accumulation while increasing hepatic insulin sensitivity in mice fed a high-fat diet. This study suggests SLC16A13 as a potential target for the treatment of type 2 diabetes and non-alcoholic fatty liver disease.Tina SchumannJörg KönigChristian von LoeffelholzDaniel F. VatnerDongyan ZhangRachel J. PerryMichel BernierJason ChamiChristine HenkeAnica KurzbachNermeen N. El-AgroudyDiana M. WillmesDominik PestaRafael de CaboJohn F. O´SullivanEric SimonGerald I. ShulmanBradford S. HamiltonAndreas L. BirkenfeldNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tina Schumann Jörg König Christian von Loeffelholz Daniel F. Vatner Dongyan Zhang Rachel J. Perry Michel Bernier Jason Chami Christine Henke Anica Kurzbach Nermeen N. El-Agroudy Diana M. Willmes Dominik Pesta Rafael de Cabo John F. O´Sullivan Eric Simon Gerald I. Shulman Bradford S. Hamilton Andreas L. Birkenfeld Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance
description	Schumann et al. demonstrate that the loss of a lactate transporter Slc16a13 increases mitochondrial respiration in the liver, which reduces hepatic lipid accumulation while increasing hepatic insulin sensitivity in mice fed a high-fat diet. This study suggests SLC16A13 as a potential target for the treatment of type 2 diabetes and non-alcoholic fatty liver disease.
format	article
author	Tina Schumann Jörg König Christian von Loeffelholz Daniel F. Vatner Dongyan Zhang Rachel J. Perry Michel Bernier Jason Chami Christine Henke Anica Kurzbach Nermeen N. El-Agroudy Diana M. Willmes Dominik Pesta Rafael de Cabo John F. O´Sullivan Eric Simon Gerald I. Shulman Bradford S. Hamilton Andreas L. Birkenfeld
author_facet	Tina Schumann Jörg König Christian von Loeffelholz Daniel F. Vatner Dongyan Zhang Rachel J. Perry Michel Bernier Jason Chami Christine Henke Anica Kurzbach Nermeen N. El-Agroudy Diana M. Willmes Dominik Pesta Rafael de Cabo John F. O´Sullivan Eric Simon Gerald I. Shulman Bradford S. Hamilton Andreas L. Birkenfeld
author_sort	Tina Schumann
title	Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance
title_short	Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance
title_full	Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance
title_fullStr	Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance
title_full_unstemmed	Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance
title_sort	deletion of the diabetes candidate gene slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ba53b89a38d4e43a575de6ad202ef08
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Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance

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