An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

The cytokine IFNα is expressed in the islets of individuals with type 1 diabetes and contributes to local inflammation and destruction of beta cells. Here, the authors provide a global multiomics view of IFNα-induced changes in human beta cells at the level of chromatin, mRNA and protein expression....

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Autores principales:	Maikel L. Colli, Mireia Ramos-Rodríguez, Ernesto S. Nakayasu, Maria I. Alvelos, Miguel Lopes, Jessica L. E. Hill, Jean-Valery Turatsinze, Alexandra Coomans de Brachène, Mark A. Russell, Helena Raurell-Vila, Angela Castela, Jonàs Juan-Mateu, Bobbie-Jo M. Webb-Robertson, Lars Krogvold, Knut Dahl-Jorgensen, Lorella Marselli, Piero Marchetti, Sarah J. Richardson, Noel G. Morgan, Thomas O. Metz, Lorenzo Pasquali, Décio L. Eizirik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ba57ffc94954c2897c0cf413d87e02a
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spelling	oai:doaj.org-article:7ba57ffc94954c2897c0cf413d87e02a2021-12-02T16:51:34ZAn integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells10.1038/s41467-020-16327-02041-1723https://doaj.org/article/7ba57ffc94954c2897c0cf413d87e02a2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16327-0https://doaj.org/toc/2041-1723The cytokine IFNα is expressed in the islets of individuals with type 1 diabetes and contributes to local inflammation and destruction of beta cells. Here, the authors provide a global multiomics view of IFNα-induced changes in human beta cells at the level of chromatin, mRNA and protein expression.Maikel L. ColliMireia Ramos-RodríguezErnesto S. NakayasuMaria I. AlvelosMiguel LopesJessica L. E. HillJean-Valery TuratsinzeAlexandra Coomans de BrachèneMark A. RussellHelena Raurell-VilaAngela CastelaJonàs Juan-MateuBobbie-Jo M. Webb-RobertsonLars KrogvoldKnut Dahl-JorgensenLorella MarselliPiero MarchettiSarah J. RichardsonNoel G. MorganThomas O. MetzLorenzo PasqualiDécio L. EizirikNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maikel L. Colli Mireia Ramos-Rodríguez Ernesto S. Nakayasu Maria I. Alvelos Miguel Lopes Jessica L. E. Hill Jean-Valery Turatsinze Alexandra Coomans de Brachène Mark A. Russell Helena Raurell-Vila Angela Castela Jonàs Juan-Mateu Bobbie-Jo M. Webb-Robertson Lars Krogvold Knut Dahl-Jorgensen Lorella Marselli Piero Marchetti Sarah J. Richardson Noel G. Morgan Thomas O. Metz Lorenzo Pasquali Décio L. Eizirik An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
description	The cytokine IFNα is expressed in the islets of individuals with type 1 diabetes and contributes to local inflammation and destruction of beta cells. Here, the authors provide a global multiomics view of IFNα-induced changes in human beta cells at the level of chromatin, mRNA and protein expression.
format	article
author	Maikel L. Colli Mireia Ramos-Rodríguez Ernesto S. Nakayasu Maria I. Alvelos Miguel Lopes Jessica L. E. Hill Jean-Valery Turatsinze Alexandra Coomans de Brachène Mark A. Russell Helena Raurell-Vila Angela Castela Jonàs Juan-Mateu Bobbie-Jo M. Webb-Robertson Lars Krogvold Knut Dahl-Jorgensen Lorella Marselli Piero Marchetti Sarah J. Richardson Noel G. Morgan Thomas O. Metz Lorenzo Pasquali Décio L. Eizirik
author_facet	Maikel L. Colli Mireia Ramos-Rodríguez Ernesto S. Nakayasu Maria I. Alvelos Miguel Lopes Jessica L. E. Hill Jean-Valery Turatsinze Alexandra Coomans de Brachène Mark A. Russell Helena Raurell-Vila Angela Castela Jonàs Juan-Mateu Bobbie-Jo M. Webb-Robertson Lars Krogvold Knut Dahl-Jorgensen Lorella Marselli Piero Marchetti Sarah J. Richardson Noel G. Morgan Thomas O. Metz Lorenzo Pasquali Décio L. Eizirik
author_sort	Maikel L. Colli
title	An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
title_short	An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
title_full	An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
title_fullStr	An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
title_full_unstemmed	An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
title_sort	integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7ba57ffc94954c2897c0cf413d87e02a
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An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

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