A Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues

Abstract Aging remains a fundamental open problem in modern biology. Although there exist a number of theories on aging on the cellular scale, nearly nothing is known about how microscopic failures cascade to macroscopic failures of tissues, organs and ultimately the organism. The goal of this work...

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Autores principales:	A. Acun, D. C. Vural, P. Zorlutuna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ba9cfe890cb43a9968f75ccd8e36e9c
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spelling	oai:doaj.org-article:7ba9cfe890cb43a9968f75ccd8e36e9c2021-12-02T12:31:55ZA Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues10.1038/s41598-017-05098-22045-2322https://doaj.org/article/7ba9cfe890cb43a9968f75ccd8e36e9c2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05098-2https://doaj.org/toc/2045-2322Abstract Aging remains a fundamental open problem in modern biology. Although there exist a number of theories on aging on the cellular scale, nearly nothing is known about how microscopic failures cascade to macroscopic failures of tissues, organs and ultimately the organism. The goal of this work is to bridge microscopic cell failure to macroscopic manifestations of aging. We use tissue engineered constructs to control the cellular-level damage and cell-cell distance in individual tissues to establish the role of complex interdependence and interactions between cells in aging tissues. We found that while microscopic mechanisms drive aging, the interdependency between cells plays a major role in tissue death, providing evidence on how cellular aging is connected to its higher systemic consequences.A. AcunD. C. VuralP. ZorlutunaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Acun D. C. Vural P. Zorlutuna A Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues
description	Abstract Aging remains a fundamental open problem in modern biology. Although there exist a number of theories on aging on the cellular scale, nearly nothing is known about how microscopic failures cascade to macroscopic failures of tissues, organs and ultimately the organism. The goal of this work is to bridge microscopic cell failure to macroscopic manifestations of aging. We use tissue engineered constructs to control the cellular-level damage and cell-cell distance in individual tissues to establish the role of complex interdependence and interactions between cells in aging tissues. We found that while microscopic mechanisms drive aging, the interdependency between cells plays a major role in tissue death, providing evidence on how cellular aging is connected to its higher systemic consequences.
format	article
author	A. Acun D. C. Vural P. Zorlutuna
author_facet	A. Acun D. C. Vural P. Zorlutuna
author_sort	A. Acun
title	A Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues
title_short	A Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues
title_full	A Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues
title_fullStr	A Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues
title_full_unstemmed	A Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues
title_sort	tissue engineered model of aging: interdependence and cooperative effects in failing tissues
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7ba9cfe890cb43a9968f75ccd8e36e9c
work_keys_str_mv	AT aacun atissueengineeredmodelofaginginterdependenceandcooperativeeffectsinfailingtissues AT dcvural atissueengineeredmodelofaginginterdependenceandcooperativeeffectsinfailingtissues AT pzorlutuna atissueengineeredmodelofaginginterdependenceandcooperativeeffectsinfailingtissues AT aacun tissueengineeredmodelofaginginterdependenceandcooperativeeffectsinfailingtissues AT dcvural tissueengineeredmodelofaginginterdependenceandcooperativeeffectsinfailingtissues AT pzorlutuna tissueengineeredmodelofaginginterdependenceandcooperativeeffectsinfailingtissues
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A Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues

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