Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

Dispatched (Disp) RND transporter, activated by Furin-mediated proteolytic cleavage, mediates the release of the lipid-modified Hedgehog (Hh) ligands. Here, the authors report structures of human Disp1 (hDisp1) before and after cleavage, and in complex with lipid-modified Sonic hedgehog (Shh), with...

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Autores principales:	Wanqiu Li, Linlin Wang, Bradley M. Wierbowski, Mo Lu, Feitong Dong, Wenchen Liu, Sisi Li, Peiyi Wang, Adrian Salic, Xin Gong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7bab0d5eed3542ad80be4acda24c43ff
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spelling	oai:doaj.org-article:7bab0d5eed3542ad80be4acda24c43ff2021-12-05T12:22:36ZStructural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release10.1038/s41467-021-27257-w2041-1723https://doaj.org/article/7bab0d5eed3542ad80be4acda24c43ff2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27257-whttps://doaj.org/toc/2041-1723Dispatched (Disp) RND transporter, activated by Furin-mediated proteolytic cleavage, mediates the release of the lipid-modified Hedgehog (Hh) ligands. Here, the authors report structures of human Disp1 (hDisp1) before and after cleavage, and in complex with lipid-modified Sonic hedgehog (Shh), with insights into the mechanisms of hDisp1 activation and function.Wanqiu LiLinlin WangBradley M. WierbowskiMo LuFeitong DongWenchen LiuSisi LiPeiyi WangAdrian SalicXin GongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wanqiu Li Linlin Wang Bradley M. Wierbowski Mo Lu Feitong Dong Wenchen Liu Sisi Li Peiyi Wang Adrian Salic Xin Gong Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release
description	Dispatched (Disp) RND transporter, activated by Furin-mediated proteolytic cleavage, mediates the release of the lipid-modified Hedgehog (Hh) ligands. Here, the authors report structures of human Disp1 (hDisp1) before and after cleavage, and in complex with lipid-modified Sonic hedgehog (Shh), with insights into the mechanisms of hDisp1 activation and function.
format	article
author	Wanqiu Li Linlin Wang Bradley M. Wierbowski Mo Lu Feitong Dong Wenchen Liu Sisi Li Peiyi Wang Adrian Salic Xin Gong
author_facet	Wanqiu Li Linlin Wang Bradley M. Wierbowski Mo Lu Feitong Dong Wenchen Liu Sisi Li Peiyi Wang Adrian Salic Xin Gong
author_sort	Wanqiu Li
title	Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release
title_short	Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release
title_full	Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release
title_fullStr	Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release
title_full_unstemmed	Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release
title_sort	structural insights into proteolytic activation of the human dispatched1 transporter for hedgehog morphogen release
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7bab0d5eed3542ad80be4acda24c43ff
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Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

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