Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

Dispatched (Disp) RND transporter, activated by Furin-mediated proteolytic cleavage, mediates the release of the lipid-modified Hedgehog (Hh) ligands. Here, the authors report structures of human Disp1 (hDisp1) before and after cleavage, and in complex with lipid-modified Sonic hedgehog (Shh), with...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Wanqiu Li, Linlin Wang, Bradley M. Wierbowski, Mo Lu, Feitong Dong, Wenchen Liu, Sisi Li, Peiyi Wang, Adrian Salic, Xin Gong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/7bab0d5eed3542ad80be4acda24c43ff
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares