Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

How PRC1 recognises and interacts with its target genes remains poorly understood. Here, the authors use genome engineering and single particle tracking to dissect how PRC1 binds to chromatin in live mouse embryonic stem cells, revealing that this repressor is highly dynamic, with only a small fract...

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Autores principales:	Miles K. Huseyin, Robert J. Klose
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7bacb3f5063e4e4d8aafcc969a45c153
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spelling	oai:doaj.org-article:7bacb3f5063e4e4d8aafcc969a45c1532021-12-02T12:09:44ZLive-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy10.1038/s41467-021-21130-62041-1723https://doaj.org/article/7bacb3f5063e4e4d8aafcc969a45c1532021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21130-6https://doaj.org/toc/2041-1723How PRC1 recognises and interacts with its target genes remains poorly understood. Here, the authors use genome engineering and single particle tracking to dissect how PRC1 binds to chromatin in live mouse embryonic stem cells, revealing that this repressor is highly dynamic, with only a small fraction stably interacting with chromatin.Miles K. HuseyinRobert J. KloseNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miles K. Huseyin Robert J. Klose Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy
description	How PRC1 recognises and interacts with its target genes remains poorly understood. Here, the authors use genome engineering and single particle tracking to dissect how PRC1 binds to chromatin in live mouse embryonic stem cells, revealing that this repressor is highly dynamic, with only a small fraction stably interacting with chromatin.
format	article
author	Miles K. Huseyin Robert J. Klose
author_facet	Miles K. Huseyin Robert J. Klose
author_sort	Miles K. Huseyin
title	Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy
title_short	Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy
title_full	Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy
title_fullStr	Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy
title_full_unstemmed	Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy
title_sort	live-cell single particle tracking of prc1 reveals a highly dynamic system with low target site occupancy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7bacb3f5063e4e4d8aafcc969a45c153
work_keys_str_mv	AT mileskhuseyin livecellsingleparticletrackingofprc1revealsahighlydynamicsystemwithlowtargetsiteoccupancy AT robertjklose livecellsingleparticletrackingofprc1revealsahighlydynamicsystemwithlowtargetsiteoccupancy
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Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

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