Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

How PRC1 recognises and interacts with its target genes remains poorly understood. Here, the authors use genome engineering and single particle tracking to dissect how PRC1 binds to chromatin in live mouse embryonic stem cells, revealing that this repressor is highly dynamic, with only a small fract...

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Autores principales: Miles K. Huseyin, Robert J. Klose
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7bacb3f5063e4e4d8aafcc969a45c153
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