SARS-CoV-2 seroprevalence among 7950 healthcare workers in the Region of Southern Denmark

Objective: Healthcare workers (HCWs) carry a pronounced risk of acquiring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of this study was to determine the seroprevalence and potential risk factors of SARS-CoV-2 infection among HCWs in the Region of Southern Denmark...

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Autores principales:	Sebastian von Huth, Søren Thue Lillevang, Birgit Thorup Røge, Jonna Skov Madsen, Christian Backer Mogensen, John Eugenio Coia, Sören Möller, Ulrik Stenz Justesen, Isik Somuncu Johansen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	SARS-CoV-2 COVID-19 Healthcare workers Seroprevalence Antibodies Epidemiology Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/7bb6bbdf2e204fea9c6a6b2bf217266c
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spelling	oai:doaj.org-article:7bb6bbdf2e204fea9c6a6b2bf217266c2021-11-30T04:14:14ZSARS-CoV-2 seroprevalence among 7950 healthcare workers in the Region of Southern Denmark1201-971210.1016/j.ijid.2021.09.023https://doaj.org/article/7bb6bbdf2e204fea9c6a6b2bf217266c2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007311https://doaj.org/toc/1201-9712Objective: Healthcare workers (HCWs) carry a pronounced risk of acquiring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of this study was to determine the seroprevalence and potential risk factors of SARS-CoV-2 infection among HCWs in the Region of Southern Denmark after the first pandemic wave in the spring of 2020. Methods: This was an observational study conducted between May and June 2020. SARS-CoV-2 IgG and IgM antibodies were measured in plasma. Participants were asked to complete a questionnaire consisting of demographic information, risk factors, and COVID-19-related symptoms. Results: A total of 7950 HCWs participated. The seroprevalence of SARS-CoV-2 antibodies was 2.1% (95% confidence interval (CI) 1.8–2.4%). Seropositive participants were significantly older (mean age 48.9 years vs 46.7 years in seronegative participants, P = 0.022) and a higher percentage had experienced at least one symptom of COVID-19 (P < 0.001). The seroprevalence was significantly higher among HCWs working on dedicated COVID-19 wards (3.5%; OR 2.02, 95% CI 1.44–2.84). Seroprevalence was significantly related to 11–50 close physical contacts per day outside work (OR 1.54, 95% CI 1.07–2.22). Conclusions: The prevalence of SARS-CoV-2 antibodies was low in HCWs. However, the occupational risk of contracting the infection was found to be higher for those working on dedicated COVID-19 wards. Further, the results imply that attention should be paid to occupational risk factors in planning pandemic preparedness.Sebastian von HuthSøren Thue LillevangBirgit Thorup RøgeJonna Skov MadsenChristian Backer MogensenJohn Eugenio CoiaSören MöllerUlrik Stenz JustesenIsik Somuncu JohansenElsevierarticleSARS-CoV-2COVID-19Healthcare workersSeroprevalenceAntibodiesEpidemiologyInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 96-102 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 Healthcare workers Seroprevalence Antibodies Epidemiology Infectious and parasitic diseases RC109-216
spellingShingle	SARS-CoV-2 COVID-19 Healthcare workers Seroprevalence Antibodies Epidemiology Infectious and parasitic diseases RC109-216 Sebastian von Huth Søren Thue Lillevang Birgit Thorup Røge Jonna Skov Madsen Christian Backer Mogensen John Eugenio Coia Sören Möller Ulrik Stenz Justesen Isik Somuncu Johansen SARS-CoV-2 seroprevalence among 7950 healthcare workers in the Region of Southern Denmark
description	Objective: Healthcare workers (HCWs) carry a pronounced risk of acquiring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of this study was to determine the seroprevalence and potential risk factors of SARS-CoV-2 infection among HCWs in the Region of Southern Denmark after the first pandemic wave in the spring of 2020. Methods: This was an observational study conducted between May and June 2020. SARS-CoV-2 IgG and IgM antibodies were measured in plasma. Participants were asked to complete a questionnaire consisting of demographic information, risk factors, and COVID-19-related symptoms. Results: A total of 7950 HCWs participated. The seroprevalence of SARS-CoV-2 antibodies was 2.1% (95% confidence interval (CI) 1.8–2.4%). Seropositive participants were significantly older (mean age 48.9 years vs 46.7 years in seronegative participants, P = 0.022) and a higher percentage had experienced at least one symptom of COVID-19 (P < 0.001). The seroprevalence was significantly higher among HCWs working on dedicated COVID-19 wards (3.5%; OR 2.02, 95% CI 1.44–2.84). Seroprevalence was significantly related to 11–50 close physical contacts per day outside work (OR 1.54, 95% CI 1.07–2.22). Conclusions: The prevalence of SARS-CoV-2 antibodies was low in HCWs. However, the occupational risk of contracting the infection was found to be higher for those working on dedicated COVID-19 wards. Further, the results imply that attention should be paid to occupational risk factors in planning pandemic preparedness.
format	article
author	Sebastian von Huth Søren Thue Lillevang Birgit Thorup Røge Jonna Skov Madsen Christian Backer Mogensen John Eugenio Coia Sören Möller Ulrik Stenz Justesen Isik Somuncu Johansen
author_facet	Sebastian von Huth Søren Thue Lillevang Birgit Thorup Røge Jonna Skov Madsen Christian Backer Mogensen John Eugenio Coia Sören Möller Ulrik Stenz Justesen Isik Somuncu Johansen
author_sort	Sebastian von Huth
title	SARS-CoV-2 seroprevalence among 7950 healthcare workers in the Region of Southern Denmark
title_short	SARS-CoV-2 seroprevalence among 7950 healthcare workers in the Region of Southern Denmark
title_full	SARS-CoV-2 seroprevalence among 7950 healthcare workers in the Region of Southern Denmark
title_fullStr	SARS-CoV-2 seroprevalence among 7950 healthcare workers in the Region of Southern Denmark
title_full_unstemmed	SARS-CoV-2 seroprevalence among 7950 healthcare workers in the Region of Southern Denmark
title_sort	sars-cov-2 seroprevalence among 7950 healthcare workers in the region of southern denmark
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7bb6bbdf2e204fea9c6a6b2bf217266c
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SARS-CoV-2 seroprevalence among 7950 healthcare workers in the Region of Southern Denmark

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