Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing

Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing

Nuclear factor-kappa B (NF-κB) signaling is regulated by ubiquitin to maintain immune homeostasis. Here the authors show that a peptidylprolyl isomerase, CYPJ, blocks TAB2/3 or LUBAC ubiquitin chain sensing and suppress NF-κB activation, with CYPJ-deficiency leading to susceptibility to inflammatory...

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Autores principales: Chunjie Sheng, Chen Yao, Ziyang Wang, Hongyuan Chen, Yu Zhao, Dazhi Xu, Haojie Huang, Wenlin Huang, Shuai Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/7bb886e5b2aa4f5c8ea397430fc385f0
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spelling oai:doaj.org-article:7bb886e5b2aa4f5c8ea397430fc385f02021-12-02T15:34:15ZCyclophilin J limits inflammation through the blockage of ubiquitin chain sensing10.1038/s41467-018-06756-32041-1723https://doaj.org/article/7bb886e5b2aa4f5c8ea397430fc385f02018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06756-3https://doaj.org/toc/2041-1723Nuclear factor-kappa B (NF-κB) signaling is regulated by ubiquitin to maintain immune homeostasis. Here the authors show that a peptidylprolyl isomerase, CYPJ, blocks TAB2/3 or LUBAC ubiquitin chain sensing and suppress NF-κB activation, with CYPJ-deficiency leading to susceptibility to inflammatory stimuli.Chunjie ShengChen YaoZiyang WangHongyuan ChenYu ZhaoDazhi XuHaojie HuangWenlin HuangShuai ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chunjie Sheng
Chen Yao
Ziyang Wang
Hongyuan Chen
Yu Zhao
Dazhi Xu
Haojie Huang
Wenlin Huang
Shuai Chen
Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing
description Nuclear factor-kappa B (NF-κB) signaling is regulated by ubiquitin to maintain immune homeostasis. Here the authors show that a peptidylprolyl isomerase, CYPJ, blocks TAB2/3 or LUBAC ubiquitin chain sensing and suppress NF-κB activation, with CYPJ-deficiency leading to susceptibility to inflammatory stimuli.
format article
author Chunjie Sheng
Chen Yao
Ziyang Wang
Hongyuan Chen
Yu Zhao
Dazhi Xu
Haojie Huang
Wenlin Huang
Shuai Chen
author_facet Chunjie Sheng
Chen Yao
Ziyang Wang
Hongyuan Chen
Yu Zhao
Dazhi Xu
Haojie Huang
Wenlin Huang
Shuai Chen
author_sort Chunjie Sheng
title Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing
title_short Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing
title_full Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing
title_fullStr Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing
title_full_unstemmed Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing
title_sort cyclophilin j limits inflammation through the blockage of ubiquitin chain sensing
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/7bb886e5b2aa4f5c8ea397430fc385f0
work_keys_str_mv AT chunjiesheng cyclophilinjlimitsinflammationthroughtheblockageofubiquitinchainsensing
AT chenyao cyclophilinjlimitsinflammationthroughtheblockageofubiquitinchainsensing
AT ziyangwang cyclophilinjlimitsinflammationthroughtheblockageofubiquitinchainsensing
AT hongyuanchen cyclophilinjlimitsinflammationthroughtheblockageofubiquitinchainsensing
AT yuzhao cyclophilinjlimitsinflammationthroughtheblockageofubiquitinchainsensing
AT dazhixu cyclophilinjlimitsinflammationthroughtheblockageofubiquitinchainsensing
AT haojiehuang cyclophilinjlimitsinflammationthroughtheblockageofubiquitinchainsensing
AT wenlinhuang cyclophilinjlimitsinflammationthroughtheblockageofubiquitinchainsensing
AT shuaichen cyclophilinjlimitsinflammationthroughtheblockageofubiquitinchainsensing
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