Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer

Abstract The use of ultrasound in the clinic has been long established for cancer detection and image-guided tissue biopsies. In addition, ultrasound-based methods have been widely explored to develop more effective cancer therapies such as localized drug delivery, sonodynamic therapy, and focused u...

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Autores principales:	Sinan Sabuncu, Adem Yildirim
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Ultrasound imaging Focused ultrasound Gas-stabilizing nanoparticles Tumor ablation Drug delivery Sonodynamic therapy Technology T Chemical technology TP1-1185 Biotechnology TP248.13-248.65 Science Q Physics QC1-999
Acceso en línea:	https://doaj.org/article/7bbb34698b1e42b6957e50fdef784afb
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spelling	oai:doaj.org-article:7bbb34698b1e42b6957e50fdef784afb2021-12-05T12:23:45ZGas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer10.1186/s40580-021-00287-22196-5404https://doaj.org/article/7bbb34698b1e42b6957e50fdef784afb2021-12-01T00:00:00Zhttps://doi.org/10.1186/s40580-021-00287-2https://doaj.org/toc/2196-5404Abstract The use of ultrasound in the clinic has been long established for cancer detection and image-guided tissue biopsies. In addition, ultrasound-based methods have been widely explored to develop more effective cancer therapies such as localized drug delivery, sonodynamic therapy, and focused ultrasound surgery. Stabilized fluorocarbon microbubbles have been in use as contrast agents for ultrasound imaging in the clinic for several decades. It is also known that microbubble cavitation could generate thermal, mechanical, and chemical effects in the tissue to improve ultrasound-based therapies. However, the large size, poor stability, and short-term cavitation activity of microbubbles limit their applications in cancer imaging and therapy. This review will focus on an alternative type of ultrasound responsive material; gas-stabilizing nanoparticles, which can address the limitations of microbubbles with their nanoscale size, robustness, and high cavitation activity. This review will be of interest to researchers who wish to explore new agents to develop improved methods for molecular ultrasound imaging and therapy of cancer.Sinan SabuncuAdem YildirimSpringerOpenarticleUltrasound imagingFocused ultrasoundGas-stabilizing nanoparticlesTumor ablationDrug deliverySonodynamic therapyTechnologyTChemical technologyTP1-1185BiotechnologyTP248.13-248.65ScienceQPhysicsQC1-999ENNano Convergence, Vol 8, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ultrasound imaging Focused ultrasound Gas-stabilizing nanoparticles Tumor ablation Drug delivery Sonodynamic therapy Technology T Chemical technology TP1-1185 Biotechnology TP248.13-248.65 Science Q Physics QC1-999
spellingShingle	Ultrasound imaging Focused ultrasound Gas-stabilizing nanoparticles Tumor ablation Drug delivery Sonodynamic therapy Technology T Chemical technology TP1-1185 Biotechnology TP248.13-248.65 Science Q Physics QC1-999 Sinan Sabuncu Adem Yildirim Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer
description	Abstract The use of ultrasound in the clinic has been long established for cancer detection and image-guided tissue biopsies. In addition, ultrasound-based methods have been widely explored to develop more effective cancer therapies such as localized drug delivery, sonodynamic therapy, and focused ultrasound surgery. Stabilized fluorocarbon microbubbles have been in use as contrast agents for ultrasound imaging in the clinic for several decades. It is also known that microbubble cavitation could generate thermal, mechanical, and chemical effects in the tissue to improve ultrasound-based therapies. However, the large size, poor stability, and short-term cavitation activity of microbubbles limit their applications in cancer imaging and therapy. This review will focus on an alternative type of ultrasound responsive material; gas-stabilizing nanoparticles, which can address the limitations of microbubbles with their nanoscale size, robustness, and high cavitation activity. This review will be of interest to researchers who wish to explore new agents to develop improved methods for molecular ultrasound imaging and therapy of cancer.
format	article
author	Sinan Sabuncu Adem Yildirim
author_facet	Sinan Sabuncu Adem Yildirim
author_sort	Sinan Sabuncu
title	Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer
title_short	Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer
title_full	Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer
title_fullStr	Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer
title_full_unstemmed	Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer
title_sort	gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/7bbb34698b1e42b6957e50fdef784afb
work_keys_str_mv	AT sinansabuncu gasstabilizingnanoparticlesforultrasoundimagingandtherapyofcancer AT ademyildirim gasstabilizingnanoparticlesforultrasoundimagingandtherapyofcancer
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Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer

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