Mapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.

Pathological and imaging data indicate that amyotrophic lateral sclerosis (ALS) is a multisystem disease involving several cerebral cortical areas. Advanced quantitative magnetic resonance imaging (MRI) techniques enable to explore in vivo the volume and microstructure of the cerebral cortex in ALS....

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Autores principales:	Mirco Cosottini, Paolo Cecchi, Selina Piazza, Ilaria Pesaresi, Serena Fabbri, Stefano Diciotti, Mario Mascalchi, Gabriele Siciliano, Ubaldo Bonuccelli
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bbbd9e649ac4e538535b35281aa42c0
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id	oai:doaj.org-article:7bbbd9e649ac4e538535b35281aa42c0
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spelling	oai:doaj.org-article:7bbbd9e649ac4e538535b35281aa42c02021-11-18T07:38:08ZMapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.1932-620310.1371/journal.pone.0068279https://doaj.org/article/7bbbd9e649ac4e538535b35281aa42c02013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874570/?tool=EBIhttps://doaj.org/toc/1932-6203Pathological and imaging data indicate that amyotrophic lateral sclerosis (ALS) is a multisystem disease involving several cerebral cortical areas. Advanced quantitative magnetic resonance imaging (MRI) techniques enable to explore in vivo the volume and microstructure of the cerebral cortex in ALS. We studied with a combined voxel-based morphometry (VBM) and magnetization transfer (MT) imaging approach the capability of MRI to identify the cortical areas affected by neurodegeneration in ALS patients. Eighteen ALS patients and 18 age-matched healthy controls were examined on a 1.5T scanner using a high-resolution 3D T1 weighted spoiled gradient recalled sequence with and without MT saturation pulse. A voxel-based analysis (VBA) was adopted in order to automatically compute the regional atrophy and MT ratio (MTr) changes of the entire cerebral cortex. By using a multimodal image analysis MTr was adjusted for local gray matter (GM) atrophy to investigate if MTr changes can be independent of atrophy of the cerebral cortex. VBA revealed several clusters of combined GM atrophy and MTr decrease in motor-related areas and extra-motor frontotemporal cortex. The multimodal image analysis identified areas of isolated MTr decrease in premotor and extra-motor frontotemporal areas. VBM and MTr are capable to detect the distribution of neurodegenerative alterations in the cortical GM of ALS patients, supporting the hypothesis of a multi-systemic involvement in ALS. MT imaging changes exist beyond volume loss in frontotemporal cortices.Mirco CosottiniPaolo CecchiSelina PiazzaIlaria PesaresiSerena FabbriStefano DiciottiMario MascalchiGabriele SicilianoUbaldo BonuccelliPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68279 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mirco Cosottini Paolo Cecchi Selina Piazza Ilaria Pesaresi Serena Fabbri Stefano Diciotti Mario Mascalchi Gabriele Siciliano Ubaldo Bonuccelli Mapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.
description	Pathological and imaging data indicate that amyotrophic lateral sclerosis (ALS) is a multisystem disease involving several cerebral cortical areas. Advanced quantitative magnetic resonance imaging (MRI) techniques enable to explore in vivo the volume and microstructure of the cerebral cortex in ALS. We studied with a combined voxel-based morphometry (VBM) and magnetization transfer (MT) imaging approach the capability of MRI to identify the cortical areas affected by neurodegeneration in ALS patients. Eighteen ALS patients and 18 age-matched healthy controls were examined on a 1.5T scanner using a high-resolution 3D T1 weighted spoiled gradient recalled sequence with and without MT saturation pulse. A voxel-based analysis (VBA) was adopted in order to automatically compute the regional atrophy and MT ratio (MTr) changes of the entire cerebral cortex. By using a multimodal image analysis MTr was adjusted for local gray matter (GM) atrophy to investigate if MTr changes can be independent of atrophy of the cerebral cortex. VBA revealed several clusters of combined GM atrophy and MTr decrease in motor-related areas and extra-motor frontotemporal cortex. The multimodal image analysis identified areas of isolated MTr decrease in premotor and extra-motor frontotemporal areas. VBM and MTr are capable to detect the distribution of neurodegenerative alterations in the cortical GM of ALS patients, supporting the hypothesis of a multi-systemic involvement in ALS. MT imaging changes exist beyond volume loss in frontotemporal cortices.
format	article
author	Mirco Cosottini Paolo Cecchi Selina Piazza Ilaria Pesaresi Serena Fabbri Stefano Diciotti Mario Mascalchi Gabriele Siciliano Ubaldo Bonuccelli
author_facet	Mirco Cosottini Paolo Cecchi Selina Piazza Ilaria Pesaresi Serena Fabbri Stefano Diciotti Mario Mascalchi Gabriele Siciliano Ubaldo Bonuccelli
author_sort	Mirco Cosottini
title	Mapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.
title_short	Mapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.
title_full	Mapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.
title_fullStr	Mapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.
title_full_unstemmed	Mapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.
title_sort	mapping cortical degeneration in als with magnetization transfer ratio and voxel-based morphometry.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7bbbd9e649ac4e538535b35281aa42c0
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Mapping cortical degeneration in ALS with magnetization transfer ratio and voxel-based morphometry.

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