Spatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi, China.

<h4>Background</h4>Amid numerous outbreaks of hand, foot and mouth disease (HFMD) in Asia over the past decade, studies on spatio-temporal clustering are limited. Without this information the distribution of severe cases assumed to be sporadic. We analyzed surveillance data with onset da...

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Autores principales:	Yi-hong Xie, Virasakdi Chongsuvivatwong, Zhenzhu Tang, Edward B McNeil, Yi Tan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bc2092ebfe449eb98da7e9bace2d115
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spelling	oai:doaj.org-article:7bc2092ebfe449eb98da7e9bace2d1152021-11-18T08:33:40ZSpatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi, China.1932-620310.1371/journal.pone.0088065https://doaj.org/article/7bc2092ebfe449eb98da7e9bace2d1152014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24505378/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Amid numerous outbreaks of hand, foot and mouth disease (HFMD) in Asia over the past decade, studies on spatio-temporal clustering are limited. Without this information the distribution of severe cases assumed to be sporadic. We analyzed surveillance data with onset dates between 1 May 2008 to 31 October 2013 with the aim to document the spatio-temporal clustering of HFMD cases and severe cases at the county level.<h4>Methods</h4>Purely temporal and purely spatial descriptive analyses were done. These were followed by a space-time scan statistic for the whole study period and by year to detect the high risk clusters based on a discrete Poisson model.<h4>Results</h4>The annual incidence rate of HFMD in Guangxi increased whereas the severe cases peaked in 2010 and 2012. EV71 and CoxA16 were alternating viruses. Both HFMD cases and severe cases had a seasonal peak in April to July. The spatio-temporal cluster of HFMD cases were mainly detected in the northeastern, central and southwestern regions, among which three clusters were observed in Nanning, Liuzhou, Guilin city and their neighbouring areas lasting from 1.2 to 2.5 years. The clusters of severe cases were less consistent in location and included around 40-70% of all severe cases in each year.<h4>Conclusions</h4>Both HFMD cases and severe cases occur in spatio-temporal clusters. The continuous epidemic in Nanning, Liuzhou, Guilin cities and their neighbouring areas and the clusters of severe cases indicate the need for further intensive surveillance.Yi-hong XieVirasakdi ChongsuvivatwongZhenzhu TangEdward B McNeilYi TanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88065 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-hong Xie Virasakdi Chongsuvivatwong Zhenzhu Tang Edward B McNeil Yi Tan Spatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi, China.
description	<h4>Background</h4>Amid numerous outbreaks of hand, foot and mouth disease (HFMD) in Asia over the past decade, studies on spatio-temporal clustering are limited. Without this information the distribution of severe cases assumed to be sporadic. We analyzed surveillance data with onset dates between 1 May 2008 to 31 October 2013 with the aim to document the spatio-temporal clustering of HFMD cases and severe cases at the county level.<h4>Methods</h4>Purely temporal and purely spatial descriptive analyses were done. These were followed by a space-time scan statistic for the whole study period and by year to detect the high risk clusters based on a discrete Poisson model.<h4>Results</h4>The annual incidence rate of HFMD in Guangxi increased whereas the severe cases peaked in 2010 and 2012. EV71 and CoxA16 were alternating viruses. Both HFMD cases and severe cases had a seasonal peak in April to July. The spatio-temporal cluster of HFMD cases were mainly detected in the northeastern, central and southwestern regions, among which three clusters were observed in Nanning, Liuzhou, Guilin city and their neighbouring areas lasting from 1.2 to 2.5 years. The clusters of severe cases were less consistent in location and included around 40-70% of all severe cases in each year.<h4>Conclusions</h4>Both HFMD cases and severe cases occur in spatio-temporal clusters. The continuous epidemic in Nanning, Liuzhou, Guilin cities and their neighbouring areas and the clusters of severe cases indicate the need for further intensive surveillance.
format	article
author	Yi-hong Xie Virasakdi Chongsuvivatwong Zhenzhu Tang Edward B McNeil Yi Tan
author_facet	Yi-hong Xie Virasakdi Chongsuvivatwong Zhenzhu Tang Edward B McNeil Yi Tan
author_sort	Yi-hong Xie
title	Spatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi, China.
title_short	Spatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi, China.
title_full	Spatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi, China.
title_fullStr	Spatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi, China.
title_full_unstemmed	Spatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi, China.
title_sort	spatio-temporal clustering of hand, foot, and mouth disease at the county level in guangxi, china.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7bc2092ebfe449eb98da7e9bace2d115
work_keys_str_mv	AT yihongxie spatiotemporalclusteringofhandfootandmouthdiseaseatthecountylevelinguangxichina AT virasakdichongsuvivatwong spatiotemporalclusteringofhandfootandmouthdiseaseatthecountylevelinguangxichina AT zhenzhutang spatiotemporalclusteringofhandfootandmouthdiseaseatthecountylevelinguangxichina AT edwardbmcneil spatiotemporalclusteringofhandfootandmouthdiseaseatthecountylevelinguangxichina AT yitan spatiotemporalclusteringofhandfootandmouthdiseaseatthecountylevelinguangxichina
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Spatio-temporal clustering of hand, foot, and mouth disease at the county level in Guangxi, China.

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