Emerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment
Wenli Zhang,1,* Enshi Hu,1,* Yajie Wang,1,* Si Miao,1 Yanyan Liu,1 Yumin Hu III,1 Ji Liu,1 Bohui Xu,2 Daquan Chen,3 Yan Shen1 1Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China; 2School of Pharmacy, Nantong University, N...
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Dove Medical Press
2021
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oai:doaj.org-article:7bc297f776744b1e8b9171265bd558cc2021-12-02T19:20:01ZEmerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment1178-2013https://doaj.org/article/7bc297f776744b1e8b9171265bd558cc2021-09-01T00:00:00Zhttps://www.dovepress.com/emerging-antibacterial-strategies-with-application-of-targeting-drug-d-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Wenli Zhang,1,* Enshi Hu,1,* Yajie Wang,1,* Si Miao,1 Yanyan Liu,1 Yumin Hu III,1 Ji Liu,1 Bohui Xu,2 Daquan Chen,3 Yan Shen1 1Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China; 2School of Pharmacy, Nantong University, Nantong, 226001, People’s Republic of China; 3School of Pharmacy, Yantai University, State Key Laboratory of Long-acting and Targeting Drug Delivery System, Yantai, 264005, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Shen; Daquan Chen Tel +86-25-83271305; +86-535-6706021Email shenyan@cpu.edu.cn; cdq1981@126.comAbstract: At present, some bacteria have developed significant resistance to almost all available antibiotics. One of the reasons that cannot be ignored is long-term exposure of bacteria to the sub-minimum inhibitory concentration (MIC) of antibiotics. Therefore, it is necessary to develop a targeted antibiotic delivery system to improve drug delivery behavior, in order to delay the generation of bacterial drug resistance. In recent years, with the continuous development of nanotechnology, various types of nanocarriers that respond to the infection microenvironment, targeting specific bacterial targets, and targeting infected cells, and so on, are gradually being used in the delivery of antibacterial agents to increase the concentration of drugs at the site of infection and reduce the side effects of drugs in normal tissues. Here, this article describes in detail the latest research progress on nanocarriers for antimicrobial, and commonly used targeted antimicrobial strategies. The advantages of the combination of nanotechnology and targeting strategies in combating bacterial infections are highlighted in this review, and the upcoming opportunities and remaining challenges in this field are rationally prospected.Keywords: nanocarriers, antimicrobial, drug delivery, targeting strategiesZhang WHu EWang YMiao SLiu YHu III YLiu JXu BChen DShen YDove Medical Pressarticlenanocarriersantimicrobialdrug deliverytargeting strategiesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 6141-6156 (2021) |
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nanocarriers antimicrobial drug delivery targeting strategies Medicine (General) R5-920 |
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nanocarriers antimicrobial drug delivery targeting strategies Medicine (General) R5-920 Zhang W Hu E Wang Y Miao S Liu Y Hu III Y Liu J Xu B Chen D Shen Y Emerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment |
| description |
Wenli Zhang,1,* Enshi Hu,1,* Yajie Wang,1,* Si Miao,1 Yanyan Liu,1 Yumin Hu III,1 Ji Liu,1 Bohui Xu,2 Daquan Chen,3 Yan Shen1 1Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China; 2School of Pharmacy, Nantong University, Nantong, 226001, People’s Republic of China; 3School of Pharmacy, Yantai University, State Key Laboratory of Long-acting and Targeting Drug Delivery System, Yantai, 264005, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Shen; Daquan Chen Tel +86-25-83271305; +86-535-6706021Email shenyan@cpu.edu.cn; cdq1981@126.comAbstract: At present, some bacteria have developed significant resistance to almost all available antibiotics. One of the reasons that cannot be ignored is long-term exposure of bacteria to the sub-minimum inhibitory concentration (MIC) of antibiotics. Therefore, it is necessary to develop a targeted antibiotic delivery system to improve drug delivery behavior, in order to delay the generation of bacterial drug resistance. In recent years, with the continuous development of nanotechnology, various types of nanocarriers that respond to the infection microenvironment, targeting specific bacterial targets, and targeting infected cells, and so on, are gradually being used in the delivery of antibacterial agents to increase the concentration of drugs at the site of infection and reduce the side effects of drugs in normal tissues. Here, this article describes in detail the latest research progress on nanocarriers for antimicrobial, and commonly used targeted antimicrobial strategies. The advantages of the combination of nanotechnology and targeting strategies in combating bacterial infections are highlighted in this review, and the upcoming opportunities and remaining challenges in this field are rationally prospected.Keywords: nanocarriers, antimicrobial, drug delivery, targeting strategies |
| format |
article |
| author |
Zhang W Hu E Wang Y Miao S Liu Y Hu III Y Liu J Xu B Chen D Shen Y |
| author_facet |
Zhang W Hu E Wang Y Miao S Liu Y Hu III Y Liu J Xu B Chen D Shen Y |
| author_sort |
Zhang W |
| title |
Emerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment |
| title_short |
Emerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment |
| title_full |
Emerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment |
| title_fullStr |
Emerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment |
| title_full_unstemmed |
Emerging Antibacterial Strategies with Application of Targeting Drug Delivery System and Combined Treatment |
| title_sort |
emerging antibacterial strategies with application of targeting drug delivery system and combined treatment |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/7bc297f776744b1e8b9171265bd558cc |
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1718376860240314368 |