Self-reported and cotinine-verified smoking and increased risk of incident hearing loss

Abstract We examined the associations of smoking status and urinary cotinine levels, an objective measure of smoking, with the development of new-onset HL. This cohort study was performed in 293,991 Korean adults free of HL who underwent a comprehensive screening examination and were followed for up...

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Autores principales:	Woncheol Lee, Yoosoo Chang, Hocheol Shin, Seungho Ryu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bc9c0bc5be845b8b35e7c01a8523d22
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spelling	oai:doaj.org-article:7bc9c0bc5be845b8b35e7c01a8523d222021-12-02T15:51:14ZSelf-reported and cotinine-verified smoking and increased risk of incident hearing loss10.1038/s41598-021-87531-12045-2322https://doaj.org/article/7bc9c0bc5be845b8b35e7c01a8523d222021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87531-1https://doaj.org/toc/2045-2322Abstract We examined the associations of smoking status and urinary cotinine levels, an objective measure of smoking, with the development of new-onset HL. This cohort study was performed in 293,991 Korean adults free of HL who underwent a comprehensive screening examination and were followed for up to 8.8 years. HL was defined as a pure-tone average of thresholds at 0.5, 1.0, and 2.0 kHz ≥ 25 dB in both ears. During a median follow-up of 4.9 years, 2286 participants developed new-onset bilateral HL. Self-reported smoking status was associated with an increased risk of new-onset bilateral HL. Multivariable-adjusted HRs (95% CIs) for incident HL comparing former smokers and current smokers to never-smokers were 1.14 (1.004–1.30) and 1.40 (1.21–1.61), respectively. Number of cigarettes, pack-years, and urinary cotinine levels were consistently associated with incident HL. These associations were similarly observed when introducing changes in smoking status, urinary cotinine, and other confounders during follow-up as time-varying covariates. In this large cohort of young and middle-aged men and women, smoking status based on both self-report and urinary cotinine level were independently associated with an increased incidence of bilateral HL. Our findings indicate smoking is an independent risk factor for HL.Woncheol LeeYoosoo ChangHocheol ShinSeungho RyuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Woncheol Lee Yoosoo Chang Hocheol Shin Seungho Ryu Self-reported and cotinine-verified smoking and increased risk of incident hearing loss
description	Abstract We examined the associations of smoking status and urinary cotinine levels, an objective measure of smoking, with the development of new-onset HL. This cohort study was performed in 293,991 Korean adults free of HL who underwent a comprehensive screening examination and were followed for up to 8.8 years. HL was defined as a pure-tone average of thresholds at 0.5, 1.0, and 2.0 kHz ≥ 25 dB in both ears. During a median follow-up of 4.9 years, 2286 participants developed new-onset bilateral HL. Self-reported smoking status was associated with an increased risk of new-onset bilateral HL. Multivariable-adjusted HRs (95% CIs) for incident HL comparing former smokers and current smokers to never-smokers were 1.14 (1.004–1.30) and 1.40 (1.21–1.61), respectively. Number of cigarettes, pack-years, and urinary cotinine levels were consistently associated with incident HL. These associations were similarly observed when introducing changes in smoking status, urinary cotinine, and other confounders during follow-up as time-varying covariates. In this large cohort of young and middle-aged men and women, smoking status based on both self-report and urinary cotinine level were independently associated with an increased incidence of bilateral HL. Our findings indicate smoking is an independent risk factor for HL.
format	article
author	Woncheol Lee Yoosoo Chang Hocheol Shin Seungho Ryu
author_facet	Woncheol Lee Yoosoo Chang Hocheol Shin Seungho Ryu
author_sort	Woncheol Lee
title	Self-reported and cotinine-verified smoking and increased risk of incident hearing loss
title_short	Self-reported and cotinine-verified smoking and increased risk of incident hearing loss
title_full	Self-reported and cotinine-verified smoking and increased risk of incident hearing loss
title_fullStr	Self-reported and cotinine-verified smoking and increased risk of incident hearing loss
title_full_unstemmed	Self-reported and cotinine-verified smoking and increased risk of incident hearing loss
title_sort	self-reported and cotinine-verified smoking and increased risk of incident hearing loss
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7bc9c0bc5be845b8b35e7c01a8523d22
work_keys_str_mv	AT woncheollee selfreportedandcotinineverifiedsmokingandincreasedriskofincidenthearingloss AT yoosoochang selfreportedandcotinineverifiedsmokingandincreasedriskofincidenthearingloss AT hocheolshin selfreportedandcotinineverifiedsmokingandincreasedriskofincidenthearingloss AT seunghoryu selfreportedandcotinineverifiedsmokingandincreasedriskofincidenthearingloss
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Self-reported and cotinine-verified smoking and increased risk of incident hearing loss

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