Aberrant aggressive behavior in a mouse model of Angelman syndrome

Abstract Angelman syndrome (AS) is a genetic neurodevelopmental disorder due to the absence of the E3-ligase protein, UBE3A. Inappropriate social interactions, usually hyper-sociability, is a part of that syndrome. In addition, clinical surveys and case reports describe aggressive behavior in AS ind...

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Autores principales:	Lilach Simchi, Hanoch Kaphzan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bcad72e3bcd46139e74d270f66bdaac
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spelling	oai:doaj.org-article:7bcad72e3bcd46139e74d270f66bdaac2021-12-02T11:46:07ZAberrant aggressive behavior in a mouse model of Angelman syndrome10.1038/s41598-020-79984-72045-2322https://doaj.org/article/7bcad72e3bcd46139e74d270f66bdaac2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79984-7https://doaj.org/toc/2045-2322Abstract Angelman syndrome (AS) is a genetic neurodevelopmental disorder due to the absence of the E3-ligase protein, UBE3A. Inappropriate social interactions, usually hyper-sociability, is a part of that syndrome. In addition, clinical surveys and case reports describe aggressive behavior in AS individuals as a severe difficulty for caretakers. A mouse model for AS recapitulates most of the human AS phenotypes. However, very few studies utilized this mouse model for investigating affiliative social behavior, and not even a single study examined aggressive behavior. Hence, the aim of the herein study was to examine affiliative and aggressive social behavior. For that, we utilized a battery of behavioral paradigms, and performed detailed analyses of these behaviors. AS mice exhibited a unique characteristic of reduced habituation towards a social stimulus in comparison to their wild-type (WT) littermates. However, overall there were no additional marked differences in affiliative social behavior. In contrast to the mild changes in affiliative behavior, there was a striking enhanced aggression in the AS mice compared to their WT littermates. The herein findings emphasize the use of AS mouse model in characterizing and measuring inappropriate aggressive behavior, and suggests these as tools for investigating therapeutic interventions aimed at attenuating aggressive behavior.Lilach SimchiHanoch KaphzanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lilach Simchi Hanoch Kaphzan Aberrant aggressive behavior in a mouse model of Angelman syndrome
description	Abstract Angelman syndrome (AS) is a genetic neurodevelopmental disorder due to the absence of the E3-ligase protein, UBE3A. Inappropriate social interactions, usually hyper-sociability, is a part of that syndrome. In addition, clinical surveys and case reports describe aggressive behavior in AS individuals as a severe difficulty for caretakers. A mouse model for AS recapitulates most of the human AS phenotypes. However, very few studies utilized this mouse model for investigating affiliative social behavior, and not even a single study examined aggressive behavior. Hence, the aim of the herein study was to examine affiliative and aggressive social behavior. For that, we utilized a battery of behavioral paradigms, and performed detailed analyses of these behaviors. AS mice exhibited a unique characteristic of reduced habituation towards a social stimulus in comparison to their wild-type (WT) littermates. However, overall there were no additional marked differences in affiliative social behavior. In contrast to the mild changes in affiliative behavior, there was a striking enhanced aggression in the AS mice compared to their WT littermates. The herein findings emphasize the use of AS mouse model in characterizing and measuring inappropriate aggressive behavior, and suggests these as tools for investigating therapeutic interventions aimed at attenuating aggressive behavior.
format	article
author	Lilach Simchi Hanoch Kaphzan
author_facet	Lilach Simchi Hanoch Kaphzan
author_sort	Lilach Simchi
title	Aberrant aggressive behavior in a mouse model of Angelman syndrome
title_short	Aberrant aggressive behavior in a mouse model of Angelman syndrome
title_full	Aberrant aggressive behavior in a mouse model of Angelman syndrome
title_fullStr	Aberrant aggressive behavior in a mouse model of Angelman syndrome
title_full_unstemmed	Aberrant aggressive behavior in a mouse model of Angelman syndrome
title_sort	aberrant aggressive behavior in a mouse model of angelman syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7bcad72e3bcd46139e74d270f66bdaac
work_keys_str_mv	AT lilachsimchi aberrantaggressivebehaviorinamousemodelofangelmansyndrome AT hanochkaphzan aberrantaggressivebehaviorinamousemodelofangelmansyndrome
_version_	1718395234595897344

Aberrant aggressive behavior in a mouse model of Angelman syndrome

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