The 3D Genome: From Structure to Function

The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled u...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tapan Kumar Mohanta, Awdhesh Kumar Mishra, Ahmed Al-Harrasi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	3D genome topologically associated domain cohesin lamin chromosome capture Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7bcb36427c024037b560fe0155856af8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7bcb36427c024037b560fe0155856af8
record_format	dspace
spelling	oai:doaj.org-article:7bcb36427c024037b560fe0155856af82021-11-11T17:04:06ZThe 3D Genome: From Structure to Function10.3390/ijms2221115851422-00671661-6596https://doaj.org/article/7bcb36427c024037b560fe0155856af82021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11585https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled us to understand the 3D spatial organization of the genome. Chromosome capture methods using a ligation approach and the visualization tool of a 3D genome browser have facilitated detailed exploration of the genome. Topologically associated domains (TADs), lamin-associated domains, CCCTC-binding factor domains, cohesin, and chromatin structures are the prominent identified components that encode the 3D structure of the genome. Although TADs are the major contributors to 3D genome organization, they are absent in <i>Arabidopsis</i>. However, a few research groups have reported the presence of TAD-like structures in the plant kingdom.Tapan Kumar MohantaAwdhesh Kumar MishraAhmed Al-HarrasiMDPI AGarticle3Dgenometopologically associated domaincohesinlaminchromosome captureBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11585, p 11585 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D genome topologically associated domain cohesin lamin chromosome capture Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	3D genome topologically associated domain cohesin lamin chromosome capture Biology (General) QH301-705.5 Chemistry QD1-999 Tapan Kumar Mohanta Awdhesh Kumar Mishra Ahmed Al-Harrasi The 3D Genome: From Structure to Function
description	The genome is the most functional part of a cell, and genomic contents are organized in a compact three-dimensional (3D) structure. The genome contains millions of nucleotide bases organized in its proper frame. Rapid development in genome sequencing and advanced microscopy techniques have enabled us to understand the 3D spatial organization of the genome. Chromosome capture methods using a ligation approach and the visualization tool of a 3D genome browser have facilitated detailed exploration of the genome. Topologically associated domains (TADs), lamin-associated domains, CCCTC-binding factor domains, cohesin, and chromatin structures are the prominent identified components that encode the 3D structure of the genome. Although TADs are the major contributors to 3D genome organization, they are absent in <i>Arabidopsis</i>. However, a few research groups have reported the presence of TAD-like structures in the plant kingdom.
format	article
author	Tapan Kumar Mohanta Awdhesh Kumar Mishra Ahmed Al-Harrasi
author_facet	Tapan Kumar Mohanta Awdhesh Kumar Mishra Ahmed Al-Harrasi
author_sort	Tapan Kumar Mohanta
title	The 3D Genome: From Structure to Function
title_short	The 3D Genome: From Structure to Function
title_full	The 3D Genome: From Structure to Function
title_fullStr	The 3D Genome: From Structure to Function
title_full_unstemmed	The 3D Genome: From Structure to Function
title_sort	3d genome: from structure to function
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7bcb36427c024037b560fe0155856af8
work_keys_str_mv	AT tapankumarmohanta the3dgenomefromstructuretofunction AT awdheshkumarmishra the3dgenomefromstructuretofunction AT ahmedalharrasi the3dgenomefromstructuretofunction AT tapankumarmohanta 3dgenomefromstructuretofunction AT awdheshkumarmishra 3dgenomefromstructuretofunction AT ahmedalharrasi 3dgenomefromstructuretofunction
_version_	1718432186166673408

The 3D Genome: From Structure to Function

Ejemplares similares