Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis

Plant materials of Warburgia ugandensis have long been used in traditional African medicine due to their broad spectrum of biological activity. Here, we describe an efficient and mild isolation of three major compounds polygodial 1a, warburganal 2a, and muzigadial 2b using Soxhlet extraction and com...

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Autores principales:	Reni Kitte, Maik Tretbar, Sarah Dluczek, Lorenz Beckmann, Peter Marquardt, Anna Duenkel, Andreas Schubert, Stephan Fricke, U. Sandy Tretbar
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Warburgia ugandensis Sesquiterpenoids Natural products isolation Cytotoxicity Cancer Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7bcc1bdd6f0e489188e94067cc7af217
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spelling	oai:doaj.org-article:7bcc1bdd6f0e489188e94067cc7af2172021-11-20T05:05:50ZChemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis2211-715610.1016/j.rechem.2021.100242https://doaj.org/article/7bcc1bdd6f0e489188e94067cc7af2172021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211715621001478https://doaj.org/toc/2211-7156Plant materials of Warburgia ugandensis have long been used in traditional African medicine due to their broad spectrum of biological activity. Here, we describe an efficient and mild isolation of three major compounds polygodial 1a, warburganal 2a, and muzigadial 2b using Soxhlet extraction and combined preparative separation methods. Furthermore, 9-deoxymuzigadial was reported for the first time from this species. Since in silico analysis predicted drug-likeness, the compounds were tested against leukemia and solid cancer cell lines as well as human primary cells in vitro. The most susceptible cells were THP-1 indicating a selective effect against monocytes pointing towards a potential treatment of monocytic leukemia. The most robust cells were primary gingival fibroblasts offering selectivity also to solid cancers. The results in this study shed new light on long-known chemical compounds from traditional medicine and pave the way for in vivo studies to advance the substances to the next level towards the use as anti-cancer drugs.Reni KitteMaik TretbarSarah DluczekLorenz BeckmannPeter MarquardtAnna DuenkelAndreas SchubertStephan FrickeU. Sandy TretbarElsevierarticleWarburgia ugandensisSesquiterpenoidsNatural products isolationCytotoxicityCancerChemistryQD1-999ENResults in Chemistry, Vol 3, Iss , Pp 100242- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Warburgia ugandensis Sesquiterpenoids Natural products isolation Cytotoxicity Cancer Chemistry QD1-999
spellingShingle	Warburgia ugandensis Sesquiterpenoids Natural products isolation Cytotoxicity Cancer Chemistry QD1-999 Reni Kitte Maik Tretbar Sarah Dluczek Lorenz Beckmann Peter Marquardt Anna Duenkel Andreas Schubert Stephan Fricke U. Sandy Tretbar Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis
description	Plant materials of Warburgia ugandensis have long been used in traditional African medicine due to their broad spectrum of biological activity. Here, we describe an efficient and mild isolation of three major compounds polygodial 1a, warburganal 2a, and muzigadial 2b using Soxhlet extraction and combined preparative separation methods. Furthermore, 9-deoxymuzigadial was reported for the first time from this species. Since in silico analysis predicted drug-likeness, the compounds were tested against leukemia and solid cancer cell lines as well as human primary cells in vitro. The most susceptible cells were THP-1 indicating a selective effect against monocytes pointing towards a potential treatment of monocytic leukemia. The most robust cells were primary gingival fibroblasts offering selectivity also to solid cancers. The results in this study shed new light on long-known chemical compounds from traditional medicine and pave the way for in vivo studies to advance the substances to the next level towards the use as anti-cancer drugs.
format	article
author	Reni Kitte Maik Tretbar Sarah Dluczek Lorenz Beckmann Peter Marquardt Anna Duenkel Andreas Schubert Stephan Fricke U. Sandy Tretbar
author_facet	Reni Kitte Maik Tretbar Sarah Dluczek Lorenz Beckmann Peter Marquardt Anna Duenkel Andreas Schubert Stephan Fricke U. Sandy Tretbar
author_sort	Reni Kitte
title	Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis
title_short	Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis
title_full	Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis
title_fullStr	Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis
title_full_unstemmed	Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis
title_sort	chemical and cytotoxic activity of three main sesquiterpenoids from warburgia ugandensis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7bcc1bdd6f0e489188e94067cc7af217
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Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis

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