Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients

BackgroundThe study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi located near the primary tumor in order to predict high and low risks of distant metastasis of non-small cell lung cancer.MethodsI...

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Autores principales:	Olga V. Pankova, Liubov A. Tashireva, Evgeny O. Rodionov, Sergey V. Miller, Sergey A. Tuzikov, Dmitry S. Pismenny, Tatiana S. Gerashchenko, Marina V. Zavyalova, Sergey V. Vtorushin, Evgeny V. Denisov, Vladimir M. Perelmuter
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	non-small cell lung cancer (NSCLC) bronchial lesion distant metastasis metastasis-free survival basal cell hyperplasia squamous cell metaplasia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7bcc58c5dc8941979d70eb6dca5b594f
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spelling	oai:doaj.org-article:7bcc58c5dc8941979d70eb6dca5b594f2021-11-10T08:05:21ZPremalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients2234-943X10.3389/fonc.2021.771802https://doaj.org/article/7bcc58c5dc8941979d70eb6dca5b594f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.771802/fullhttps://doaj.org/toc/2234-943XBackgroundThe study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi located near the primary tumor in order to predict high and low risks of distant metastasis of non-small cell lung cancer.MethodsIn 171 patients with non-small cell lung cancer (T1-4N0-3M0) in small-caliber bronchi taken at a distance of 3–5 cm from the tumor, various variants of morphological changes in the bronchial epithelium (basal cell hyperplasia (BCH), squamous cell metaplasia (SM), and dysplasia (D)) were assessed. Long-term results of treatment, namely, distant metastasis, were assessed after 2 and 5 years.ResultsDuring the follow-up period, distant metastases were found in 35.1% (60/171) of patients. Most often, they were observed in patients of the high-risk group: BCH+SM−D− (51.6%, 40/95) and BCH−SM+D+ (54.4%, 6/11). Less often, distant metastases were observed in low-risk group patients: BCH+SM+D− (6.7%, 3/45) and BCH−SM−D− (10.0%, 2/20). Tumor size, grade, and stage were significant predictors of metastasis only in the high-risk group. The 5-year metastasis-free survival was better in the low-risk group of distant metastases.ConclusionsIsolated BCH or dysplasia in small bronchi distant from foci of tumor is associated with a high-risk distant metastasis and less 5-year metastasis-free survival.Olga V. PankovaLiubov A. TashirevaEvgeny O. RodionovSergey V. MillerSergey A. TuzikovDmitry S. PismennyTatiana S. GerashchenkoMarina V. ZavyalovaMarina V. ZavyalovaSergey V. VtorushinSergey V. VtorushinEvgeny V. DenisovEvgeny V. DenisovVladimir M. PerelmuterFrontiers Media S.A.articlenon-small cell lung cancer (NSCLC)bronchial lesiondistant metastasismetastasis-free survivalbasal cell hyperplasiasquamous cell metaplasiaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-small cell lung cancer (NSCLC) bronchial lesion distant metastasis metastasis-free survival basal cell hyperplasia squamous cell metaplasia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	non-small cell lung cancer (NSCLC) bronchial lesion distant metastasis metastasis-free survival basal cell hyperplasia squamous cell metaplasia Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Olga V. Pankova Liubov A. Tashireva Evgeny O. Rodionov Sergey V. Miller Sergey A. Tuzikov Dmitry S. Pismenny Tatiana S. Gerashchenko Marina V. Zavyalova Marina V. Zavyalova Sergey V. Vtorushin Sergey V. Vtorushin Evgeny V. Denisov Evgeny V. Denisov Vladimir M. Perelmuter Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients
description	BackgroundThe study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi located near the primary tumor in order to predict high and low risks of distant metastasis of non-small cell lung cancer.MethodsIn 171 patients with non-small cell lung cancer (T1-4N0-3M0) in small-caliber bronchi taken at a distance of 3–5 cm from the tumor, various variants of morphological changes in the bronchial epithelium (basal cell hyperplasia (BCH), squamous cell metaplasia (SM), and dysplasia (D)) were assessed. Long-term results of treatment, namely, distant metastasis, were assessed after 2 and 5 years.ResultsDuring the follow-up period, distant metastases were found in 35.1% (60/171) of patients. Most often, they were observed in patients of the high-risk group: BCH+SM−D− (51.6%, 40/95) and BCH−SM+D+ (54.4%, 6/11). Less often, distant metastases were observed in low-risk group patients: BCH+SM+D− (6.7%, 3/45) and BCH−SM−D− (10.0%, 2/20). Tumor size, grade, and stage were significant predictors of metastasis only in the high-risk group. The 5-year metastasis-free survival was better in the low-risk group of distant metastases.ConclusionsIsolated BCH or dysplasia in small bronchi distant from foci of tumor is associated with a high-risk distant metastasis and less 5-year metastasis-free survival.
format	article
author	Olga V. Pankova Liubov A. Tashireva Evgeny O. Rodionov Sergey V. Miller Sergey A. Tuzikov Dmitry S. Pismenny Tatiana S. Gerashchenko Marina V. Zavyalova Marina V. Zavyalova Sergey V. Vtorushin Sergey V. Vtorushin Evgeny V. Denisov Evgeny V. Denisov Vladimir M. Perelmuter
author_facet	Olga V. Pankova Liubov A. Tashireva Evgeny O. Rodionov Sergey V. Miller Sergey A. Tuzikov Dmitry S. Pismenny Tatiana S. Gerashchenko Marina V. Zavyalova Marina V. Zavyalova Sergey V. Vtorushin Sergey V. Vtorushin Evgeny V. Denisov Evgeny V. Denisov Vladimir M. Perelmuter
author_sort	Olga V. Pankova
title	Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients
title_short	Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients
title_full	Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients
title_fullStr	Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients
title_full_unstemmed	Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients
title_sort	premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in non-small cell lung cancer patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7bcc58c5dc8941979d70eb6dca5b594f
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Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients

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