Personality traits as risk factors for treatment-resistant depression.

<h4>Background</h4>The clinical outcome of antidepressant treatment in patients with major depressive disorder (MDD) is thought to be associated with personality traits. A number of studies suggest that depressed patients show high harm avoidance, low self-directedness and cooperativenes...

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Autores principales:	Michio Takahashi, Yukihiko Shirayama, Katsumasa Muneoka, Masatoshi Suzuki, Koichi Sato, Kenji Hashimoto
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bcdeafa4d5947eca20104aa6197348d
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spelling	oai:doaj.org-article:7bcdeafa4d5947eca20104aa6197348d2021-11-18T07:44:41ZPersonality traits as risk factors for treatment-resistant depression.1932-620310.1371/journal.pone.0063756https://doaj.org/article/7bcdeafa4d5947eca20104aa6197348d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23717477/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The clinical outcome of antidepressant treatment in patients with major depressive disorder (MDD) is thought to be associated with personality traits. A number of studies suggest that depressed patients show high harm avoidance, low self-directedness and cooperativeness, as measured on the Temperament and Character Inventory (TCI). However, the psychology of these patients is not well documented.<h4>Methods</h4>Psychological evaluation using Cloninger's TCI, was performed on treatment-resistant MDD patients (n = 35), remission MDD patients (n = 31), and age- and gender-matched healthy controls (n = 174).<h4>Results</h4>Treatment-resistant patients demonstrated high scores for harm avoidance, and low scores for reward dependence, self-directedness, and cooperativeness using the TCI, compared with healthy controls and remission patients. Interestingly, patients in remission continued to show significantly high scores for harm avoidance, but not other traits in the TCI compared with controls. Moreover, there was a significant negative correlation between reward dependence and harm avoidance in the treatment-resistant depression cohort, which was absent in the control and remitted depression groups.<h4>Conclusions</h4>This study suggests that low reward dependence and to a lesser extent, low cooperativeness in the TCI may be risk factors for treatment-resistant depression.Michio TakahashiYukihiko ShirayamaKatsumasa MuneokaMasatoshi SuzukiKoichi SatoKenji HashimotoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63756 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michio Takahashi Yukihiko Shirayama Katsumasa Muneoka Masatoshi Suzuki Koichi Sato Kenji Hashimoto Personality traits as risk factors for treatment-resistant depression.
description	<h4>Background</h4>The clinical outcome of antidepressant treatment in patients with major depressive disorder (MDD) is thought to be associated with personality traits. A number of studies suggest that depressed patients show high harm avoidance, low self-directedness and cooperativeness, as measured on the Temperament and Character Inventory (TCI). However, the psychology of these patients is not well documented.<h4>Methods</h4>Psychological evaluation using Cloninger's TCI, was performed on treatment-resistant MDD patients (n = 35), remission MDD patients (n = 31), and age- and gender-matched healthy controls (n = 174).<h4>Results</h4>Treatment-resistant patients demonstrated high scores for harm avoidance, and low scores for reward dependence, self-directedness, and cooperativeness using the TCI, compared with healthy controls and remission patients. Interestingly, patients in remission continued to show significantly high scores for harm avoidance, but not other traits in the TCI compared with controls. Moreover, there was a significant negative correlation between reward dependence and harm avoidance in the treatment-resistant depression cohort, which was absent in the control and remitted depression groups.<h4>Conclusions</h4>This study suggests that low reward dependence and to a lesser extent, low cooperativeness in the TCI may be risk factors for treatment-resistant depression.
format	article
author	Michio Takahashi Yukihiko Shirayama Katsumasa Muneoka Masatoshi Suzuki Koichi Sato Kenji Hashimoto
author_facet	Michio Takahashi Yukihiko Shirayama Katsumasa Muneoka Masatoshi Suzuki Koichi Sato Kenji Hashimoto
author_sort	Michio Takahashi
title	Personality traits as risk factors for treatment-resistant depression.
title_short	Personality traits as risk factors for treatment-resistant depression.
title_full	Personality traits as risk factors for treatment-resistant depression.
title_fullStr	Personality traits as risk factors for treatment-resistant depression.
title_full_unstemmed	Personality traits as risk factors for treatment-resistant depression.
title_sort	personality traits as risk factors for treatment-resistant depression.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7bcdeafa4d5947eca20104aa6197348d
work_keys_str_mv	AT michiotakahashi personalitytraitsasriskfactorsfortreatmentresistantdepression AT yukihikoshirayama personalitytraitsasriskfactorsfortreatmentresistantdepression AT katsumasamuneoka personalitytraitsasriskfactorsfortreatmentresistantdepression AT masatoshisuzuki personalitytraitsasriskfactorsfortreatmentresistantdepression AT koichisato personalitytraitsasriskfactorsfortreatmentresistantdepression AT kenjihashimoto personalitytraitsasriskfactorsfortreatmentresistantdepression
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Personality traits as risk factors for treatment-resistant depression.

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