Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton

Light-based modulation of the microtubule (MT) cytoskeleton is an attractive goal for spatiotemporally-resolved MT studies. Here the authors develop a first generation photoswitchable small molecule MT stabiliser based on paclitaxel, allowing optical control over cellular MT dynamics.

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Autores principales:	Adrian Müller-Deku, Joyce C. M. Meiring, Kristina Loy, Yvonne Kraus, Constanze Heise, Rebekkah Bingham, Klara I. Jansen, Xiaoyi Qu, Francesca Bartolini, Lukas C. Kapitein, Anna Akhmanova, Julia Ahlfeld, Dirk Trauner, Oliver Thorn-Seshold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7bcf664fe4af450d8c4108a5407f14ce
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spelling	oai:doaj.org-article:7bcf664fe4af450d8c4108a5407f14ce2021-12-02T15:16:10ZPhotoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton10.1038/s41467-020-18389-62041-1723https://doaj.org/article/7bcf664fe4af450d8c4108a5407f14ce2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18389-6https://doaj.org/toc/2041-1723Light-based modulation of the microtubule (MT) cytoskeleton is an attractive goal for spatiotemporally-resolved MT studies. Here the authors develop a first generation photoswitchable small molecule MT stabiliser based on paclitaxel, allowing optical control over cellular MT dynamics.Adrian Müller-DekuJoyce C. M. MeiringKristina LoyYvonne KrausConstanze HeiseRebekkah BinghamKlara I. JansenXiaoyi QuFrancesca BartoliniLukas C. KapiteinAnna AkhmanovaJulia AhlfeldDirk TraunerOliver Thorn-SesholdNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adrian Müller-Deku Joyce C. M. Meiring Kristina Loy Yvonne Kraus Constanze Heise Rebekkah Bingham Klara I. Jansen Xiaoyi Qu Francesca Bartolini Lukas C. Kapitein Anna Akhmanova Julia Ahlfeld Dirk Trauner Oliver Thorn-Seshold Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton
description	Light-based modulation of the microtubule (MT) cytoskeleton is an attractive goal for spatiotemporally-resolved MT studies. Here the authors develop a first generation photoswitchable small molecule MT stabiliser based on paclitaxel, allowing optical control over cellular MT dynamics.
format	article
author	Adrian Müller-Deku Joyce C. M. Meiring Kristina Loy Yvonne Kraus Constanze Heise Rebekkah Bingham Klara I. Jansen Xiaoyi Qu Francesca Bartolini Lukas C. Kapitein Anna Akhmanova Julia Ahlfeld Dirk Trauner Oliver Thorn-Seshold
author_facet	Adrian Müller-Deku Joyce C. M. Meiring Kristina Loy Yvonne Kraus Constanze Heise Rebekkah Bingham Klara I. Jansen Xiaoyi Qu Francesca Bartolini Lukas C. Kapitein Anna Akhmanova Julia Ahlfeld Dirk Trauner Oliver Thorn-Seshold
author_sort	Adrian Müller-Deku
title	Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton
title_short	Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton
title_full	Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton
title_fullStr	Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton
title_full_unstemmed	Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton
title_sort	photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7bcf664fe4af450d8c4108a5407f14ce
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Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton

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