Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton

Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton

Light-based modulation of the microtubule (MT) cytoskeleton is an attractive goal for spatiotemporally-resolved MT studies. Here the authors develop a first generation photoswitchable small molecule MT stabiliser based on paclitaxel, allowing optical control over cellular MT dynamics.

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Detalles Bibliográficos
Autores principales: Adrian Müller-Deku, Joyce C. M. Meiring, Kristina Loy, Yvonne Kraus, Constanze Heise, Rebekkah Bingham, Klara I. Jansen, Xiaoyi Qu, Francesca Bartolini, Lukas C. Kapitein, Anna Akhmanova, Julia Ahlfeld, Dirk Trauner, Oliver Thorn-Seshold
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/7bcf664fe4af450d8c4108a5407f14ce
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