ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling

SLIT-ROBO alterations arise in pancreatic ductal adenocarcinoma (PDAC), but their role in the pancreas is unclear. Here, the authors use mouse models to show that loss of epithelial Robo2 activates the neighbouring stroma via TGF-β signalling; findings are relevant to PDAC patients, where ROBO expr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andreia V. Pinho, Mathias Van Bulck, Lorraine Chantrill, Mehreen Arshi, Tatyana Sklyarova, David Herrmann, Claire Vennin, David Gallego-Ortega, Amanda Mawson, Marc Giry-Laterriere, Astrid Magenau, Gunther Leuckx, Luc Baeyens, Anthony J. Gill, Phoebe Phillips, Paul Timpson, Andrew V. Biankin, Jianmin Wu, Ilse Rooman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7bcf752c0ac345e8b916a29cc45a9a4f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7bcf752c0ac345e8b916a29cc45a9a4f
record_format	dspace
spelling	oai:doaj.org-article:7bcf752c0ac345e8b916a29cc45a9a4f2021-12-02T17:32:00ZROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling10.1038/s41467-018-07497-z2041-1723https://doaj.org/article/7bcf752c0ac345e8b916a29cc45a9a4f2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07497-zhttps://doaj.org/toc/2041-1723SLIT-ROBO alterations arise in pancreatic ductal adenocarcinoma (PDAC), but their role in the pancreas is unclear. Here, the authors use mouse models to show that loss of epithelial Robo2 activates the neighbouring stroma via TGF-β signalling; findings are relevant to PDAC patients, where ROBO expression correlates with survival outcomes.Andreia V. PinhoMathias Van BulckLorraine ChantrillMehreen ArshiTatyana SklyarovaDavid HerrmannClaire VenninDavid Gallego-OrtegaAmanda MawsonMarc Giry-LaterriereAstrid MagenauGunther LeuckxLuc BaeyensAnthony J. GillPhoebe PhillipsPaul TimpsonAndrew V. BiankinJianmin WuIlse RoomanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andreia V. Pinho Mathias Van Bulck Lorraine Chantrill Mehreen Arshi Tatyana Sklyarova David Herrmann Claire Vennin David Gallego-Ortega Amanda Mawson Marc Giry-Laterriere Astrid Magenau Gunther Leuckx Luc Baeyens Anthony J. Gill Phoebe Phillips Paul Timpson Andrew V. Biankin Jianmin Wu Ilse Rooman ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
description	SLIT-ROBO alterations arise in pancreatic ductal adenocarcinoma (PDAC), but their role in the pancreas is unclear. Here, the authors use mouse models to show that loss of epithelial Robo2 activates the neighbouring stroma via TGF-β signalling; findings are relevant to PDAC patients, where ROBO expression correlates with survival outcomes.
format	article
author	Andreia V. Pinho Mathias Van Bulck Lorraine Chantrill Mehreen Arshi Tatyana Sklyarova David Herrmann Claire Vennin David Gallego-Ortega Amanda Mawson Marc Giry-Laterriere Astrid Magenau Gunther Leuckx Luc Baeyens Anthony J. Gill Phoebe Phillips Paul Timpson Andrew V. Biankin Jianmin Wu Ilse Rooman
author_facet	Andreia V. Pinho Mathias Van Bulck Lorraine Chantrill Mehreen Arshi Tatyana Sklyarova David Herrmann Claire Vennin David Gallego-Ortega Amanda Mawson Marc Giry-Laterriere Astrid Magenau Gunther Leuckx Luc Baeyens Anthony J. Gill Phoebe Phillips Paul Timpson Andrew V. Biankin Jianmin Wu Ilse Rooman
author_sort	Andreia V. Pinho
title	ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
title_short	ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
title_full	ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
title_fullStr	ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
title_full_unstemmed	ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
title_sort	robo2 is a stroma suppressor gene in the pancreas and acts via tgf-β signalling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7bcf752c0ac345e8b916a29cc45a9a4f
work_keys_str_mv	AT andreiavpinho robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT mathiasvanbulck robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT lorrainechantrill robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT mehreenarshi robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT tatyanasklyarova robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT davidherrmann robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT clairevennin robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT davidgallegoortega robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT amandamawson robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT marcgirylaterriere robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT astridmagenau robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT guntherleuckx robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT lucbaeyens robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT anthonyjgill robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT phoebephillips robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT paultimpson robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT andrewvbiankin robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT jianminwu robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling AT ilserooman robo2isastromasuppressorgeneinthepancreasandactsviatgfbsignalling
_version_	1718380437787639808

ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling

Ejemplares similares