Chapter 7: Pharmacogenomics.

There is great variation in drug-response phenotypes, and a "one size fits all" paradigm for drug delivery is flawed. Pharmacogenomics is the study of how human genetic information impacts drug response, and it aims to improve efficacy and reduced side effects. In this article, we provide...

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Autores principales:	Konrad J Karczewski, Roxana Daneshjou, Russ B Altman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7bcf7ac2ddb643b0b170a7c522863b91
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spelling	oai:doaj.org-article:7bcf7ac2ddb643b0b170a7c522863b912021-11-18T05:52:36ZChapter 7: Pharmacogenomics.1553-734X1553-735810.1371/journal.pcbi.1002817https://doaj.org/article/7bcf7ac2ddb643b0b170a7c522863b912012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300409/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358There is great variation in drug-response phenotypes, and a "one size fits all" paradigm for drug delivery is flawed. Pharmacogenomics is the study of how human genetic information impacts drug response, and it aims to improve efficacy and reduced side effects. In this article, we provide an overview of pharmacogenetics, including pharmacokinetics (PK), pharmacodynamics (PD), gene and pathway interactions, and off-target effects. We describe methods for discovering genetic factors in drug response, including genome-wide association studies (GWAS), expression analysis, and other methods such as chemoinformatics and natural language processing (NLP). We cover the practical applications of pharmacogenomics both in the pharmaceutical industry and in a clinical setting. In drug discovery, pharmacogenomics can be used to aid lead identification, anticipate adverse events, and assist in drug repurposing efforts. Moreover, pharmacogenomic discoveries show promise as important elements of physician decision support. Finally, we consider the ethical, regulatory, and reimbursement challenges that remain for the clinical implementation of pharmacogenomics.Konrad J KarczewskiKonrad J KarczewskiRoxana DaneshjouRuss B AltmanPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 12, p e1002817 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Konrad J Karczewski Konrad J Karczewski Roxana Daneshjou Russ B Altman Chapter 7: Pharmacogenomics.
description	There is great variation in drug-response phenotypes, and a "one size fits all" paradigm for drug delivery is flawed. Pharmacogenomics is the study of how human genetic information impacts drug response, and it aims to improve efficacy and reduced side effects. In this article, we provide an overview of pharmacogenetics, including pharmacokinetics (PK), pharmacodynamics (PD), gene and pathway interactions, and off-target effects. We describe methods for discovering genetic factors in drug response, including genome-wide association studies (GWAS), expression analysis, and other methods such as chemoinformatics and natural language processing (NLP). We cover the practical applications of pharmacogenomics both in the pharmaceutical industry and in a clinical setting. In drug discovery, pharmacogenomics can be used to aid lead identification, anticipate adverse events, and assist in drug repurposing efforts. Moreover, pharmacogenomic discoveries show promise as important elements of physician decision support. Finally, we consider the ethical, regulatory, and reimbursement challenges that remain for the clinical implementation of pharmacogenomics.
format	article
author	Konrad J Karczewski Konrad J Karczewski Roxana Daneshjou Russ B Altman
author_facet	Konrad J Karczewski Konrad J Karczewski Roxana Daneshjou Russ B Altman
author_sort	Konrad J Karczewski
title	Chapter 7: Pharmacogenomics.
title_short	Chapter 7: Pharmacogenomics.
title_full	Chapter 7: Pharmacogenomics.
title_fullStr	Chapter 7: Pharmacogenomics.
title_full_unstemmed	Chapter 7: Pharmacogenomics.
title_sort	chapter 7: pharmacogenomics.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/7bcf7ac2ddb643b0b170a7c522863b91
work_keys_str_mv	AT konradjkarczewski chapter7pharmacogenomics AT konradjkarczewski chapter7pharmacogenomics AT roxanadaneshjou chapter7pharmacogenomics AT russbaltman chapter7pharmacogenomics
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Chapter 7: Pharmacogenomics.

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