Ratiometric fluorescent probe with AIE property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells

Abstract Hydrogen peroxide (H2O2) plays a key role in the progression of human illnesses, such as autoimmune and auto-inflammatory diseases, infectious diseases, diabetes, and cancer, etc. In this work, we have discribed a novel probe, TPE-TLE, which remarkably displayed AIE property and ratiometric...

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Autores principales:	Yong Liu, Jing Nie, Jie Niu, Fangfang Meng, Weiying Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bcf8ff7545a4311be798c3766cb91c5
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spelling	oai:doaj.org-article:7bcf8ff7545a4311be798c3766cb91c52021-12-02T16:06:14ZRatiometric fluorescent probe with AIE property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells10.1038/s41598-017-07465-52045-2322https://doaj.org/article/7bcf8ff7545a4311be798c3766cb91c52017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07465-5https://doaj.org/toc/2045-2322Abstract Hydrogen peroxide (H2O2) plays a key role in the progression of human illnesses, such as autoimmune and auto-inflammatory diseases, infectious diseases, diabetes, and cancer, etc. In this work, we have discribed a novel probe, TPE-TLE, which remarkably displayed AIE property and ratiometric fluorescence emission profiles in the presence of H2O2. This ratiometric fluorescent probe with AIE property exhibits outstanding features such as the well-resolved emission peaks, high sensitivity, high selectivity, low cytotoxicity, and good cell-membrane permeability. These excellent attributes enable us to demonstrate the ratiometric imaging of endogenously produced H2O2 in macrophages and cancer cells based on the novel ratiometric probe with AIE property for the first time. By comparing two kinds of cells, it is firstly found that cancer cells should contain much more endogenous H2O2 than macrophages. We expect that TPE-TLE will be useful fluorescent platform for the development of a variety of ratiometric fluorescent probes with AIE property to achieve unique biological applications.Yong LiuJing NieJie NiuFangfang MengWeiying LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong Liu Jing Nie Jie Niu Fangfang Meng Weiying Lin Ratiometric fluorescent probe with AIE property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells
description	Abstract Hydrogen peroxide (H2O2) plays a key role in the progression of human illnesses, such as autoimmune and auto-inflammatory diseases, infectious diseases, diabetes, and cancer, etc. In this work, we have discribed a novel probe, TPE-TLE, which remarkably displayed AIE property and ratiometric fluorescence emission profiles in the presence of H2O2. This ratiometric fluorescent probe with AIE property exhibits outstanding features such as the well-resolved emission peaks, high sensitivity, high selectivity, low cytotoxicity, and good cell-membrane permeability. These excellent attributes enable us to demonstrate the ratiometric imaging of endogenously produced H2O2 in macrophages and cancer cells based on the novel ratiometric probe with AIE property for the first time. By comparing two kinds of cells, it is firstly found that cancer cells should contain much more endogenous H2O2 than macrophages. We expect that TPE-TLE will be useful fluorescent platform for the development of a variety of ratiometric fluorescent probes with AIE property to achieve unique biological applications.
format	article
author	Yong Liu Jing Nie Jie Niu Fangfang Meng Weiying Lin
author_facet	Yong Liu Jing Nie Jie Niu Fangfang Meng Weiying Lin
author_sort	Yong Liu
title	Ratiometric fluorescent probe with AIE property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells
title_short	Ratiometric fluorescent probe with AIE property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells
title_full	Ratiometric fluorescent probe with AIE property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells
title_fullStr	Ratiometric fluorescent probe with AIE property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells
title_full_unstemmed	Ratiometric fluorescent probe with AIE property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells
title_sort	ratiometric fluorescent probe with aie property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7bcf8ff7545a4311be798c3766cb91c5
work_keys_str_mv	AT yongliu ratiometricfluorescentprobewithaiepropertyformonitoringendogenoushydrogenperoxideinmacrophagesandcancercells AT jingnie ratiometricfluorescentprobewithaiepropertyformonitoringendogenoushydrogenperoxideinmacrophagesandcancercells AT jieniu ratiometricfluorescentprobewithaiepropertyformonitoringendogenoushydrogenperoxideinmacrophagesandcancercells AT fangfangmeng ratiometricfluorescentprobewithaiepropertyformonitoringendogenoushydrogenperoxideinmacrophagesandcancercells AT weiyinglin ratiometricfluorescentprobewithaiepropertyformonitoringendogenoushydrogenperoxideinmacrophagesandcancercells
_version_	1718385096568864768

Ratiometric fluorescent probe with AIE property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells

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