Ventral tegmental area inactivation suppresses the expression of CA1 long term potentiation in anesthetized rat.

The hippocampus receives dopaminergic projections from the ventral tegmental area (VTA). Modulatory effect of dopamine on hippocampal long term potentiation (LTP) has been studied before, but there are conflicting results and some limitations in previous reports. Most of these studies show a signifi...

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Autores principales:	Elham Ghanbarian, Fereshteh Motamedi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bcf9a1a137b4132ababca367ed6d02f
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spelling	oai:doaj.org-article:7bcf9a1a137b4132ababca367ed6d02f2021-11-18T07:53:56ZVentral tegmental area inactivation suppresses the expression of CA1 long term potentiation in anesthetized rat.1932-620310.1371/journal.pone.0058844https://doaj.org/article/7bcf9a1a137b4132ababca367ed6d02f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23536829/?tool=EBIhttps://doaj.org/toc/1932-6203The hippocampus receives dopaminergic projections from the ventral tegmental area (VTA). Modulatory effect of dopamine on hippocampal long term potentiation (LTP) has been studied before, but there are conflicting results and some limitations in previous reports. Most of these studies show a significant effect of dopamine on the late phase of LTP in CA1 area of the hippocampus, while few reports show an effect on the early phase. Moreover, they generally manipulated dopamine receptors in the hippocampus and there are few studies investigating influence of the VTA neural activity on hippocampal LTP in the intact brain. Besides, VTA neurons contain other neurotransmitters such as glutamate and GABA that may modify the net effect of dopamine. In this study we examined the effect of VTA reversible inactivation on the induction and maintenance of early LTP in the CA1 area of anesthetized rats, and also on different phases of learning of a passive avoidance (PA) task. We found that inactivation of the VTA by lidocaine had no effect on CA1 LTP induction and paired-pulse facilitation, but its inactivation immediately after tetanic stimulation transiently suppressed the expression of LTP. Blockade of the VTA 20 min after tetanic stimulation had no effect on the magnitude of LTP. Moreover, VTA inactivation immediately after training impaired memory in the passive avoidance task, while its blockade before or 20 min after training produced no memory deficit. It can be concluded that VTA activity has no effect on CA1 LTP induction and acquisition of PA task, but involves in the expression of LTP and PA memory consolidation.Elham GhanbarianFereshteh MotamediPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58844 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elham Ghanbarian Fereshteh Motamedi Ventral tegmental area inactivation suppresses the expression of CA1 long term potentiation in anesthetized rat.
description	The hippocampus receives dopaminergic projections from the ventral tegmental area (VTA). Modulatory effect of dopamine on hippocampal long term potentiation (LTP) has been studied before, but there are conflicting results and some limitations in previous reports. Most of these studies show a significant effect of dopamine on the late phase of LTP in CA1 area of the hippocampus, while few reports show an effect on the early phase. Moreover, they generally manipulated dopamine receptors in the hippocampus and there are few studies investigating influence of the VTA neural activity on hippocampal LTP in the intact brain. Besides, VTA neurons contain other neurotransmitters such as glutamate and GABA that may modify the net effect of dopamine. In this study we examined the effect of VTA reversible inactivation on the induction and maintenance of early LTP in the CA1 area of anesthetized rats, and also on different phases of learning of a passive avoidance (PA) task. We found that inactivation of the VTA by lidocaine had no effect on CA1 LTP induction and paired-pulse facilitation, but its inactivation immediately after tetanic stimulation transiently suppressed the expression of LTP. Blockade of the VTA 20 min after tetanic stimulation had no effect on the magnitude of LTP. Moreover, VTA inactivation immediately after training impaired memory in the passive avoidance task, while its blockade before or 20 min after training produced no memory deficit. It can be concluded that VTA activity has no effect on CA1 LTP induction and acquisition of PA task, but involves in the expression of LTP and PA memory consolidation.
format	article
author	Elham Ghanbarian Fereshteh Motamedi
author_facet	Elham Ghanbarian Fereshteh Motamedi
author_sort	Elham Ghanbarian
title	Ventral tegmental area inactivation suppresses the expression of CA1 long term potentiation in anesthetized rat.
title_short	Ventral tegmental area inactivation suppresses the expression of CA1 long term potentiation in anesthetized rat.
title_full	Ventral tegmental area inactivation suppresses the expression of CA1 long term potentiation in anesthetized rat.
title_fullStr	Ventral tegmental area inactivation suppresses the expression of CA1 long term potentiation in anesthetized rat.
title_full_unstemmed	Ventral tegmental area inactivation suppresses the expression of CA1 long term potentiation in anesthetized rat.
title_sort	ventral tegmental area inactivation suppresses the expression of ca1 long term potentiation in anesthetized rat.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7bcf9a1a137b4132ababca367ed6d02f
work_keys_str_mv	AT elhamghanbarian ventraltegmentalareainactivationsuppressestheexpressionofca1longtermpotentiationinanesthetizedrat AT fereshtehmotamedi ventraltegmentalareainactivationsuppressestheexpressionofca1longtermpotentiationinanesthetizedrat
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Ventral tegmental area inactivation suppresses the expression of CA1 long term potentiation in anesthetized rat.

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