Bio-implant as a novel restoration for tooth loss

Abstract A dental implant is used to replace a missing tooth. Fixing the implant in its natural position requires the engineering of a substantial amount of conformal bone growth inside the implant socket, osseointegration. However, this conventional implant attachment does not include the periodont...

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Autores principales:	Dong-Joon Lee, Jong-Min Lee, Eun-Jung Kim, Takashi Takata, Yoshihiro Abiko, Teruo Okano, David W. Green, Masaki Shimono, Han-Sung Jung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bd496afab284c61877c6ae73b08ca81
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spelling	oai:doaj.org-article:7bd496afab284c61877c6ae73b08ca812021-12-02T12:32:53ZBio-implant as a novel restoration for tooth loss10.1038/s41598-017-07819-z2045-2322https://doaj.org/article/7bd496afab284c61877c6ae73b08ca812017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07819-zhttps://doaj.org/toc/2045-2322Abstract A dental implant is used to replace a missing tooth. Fixing the implant in its natural position requires the engineering of a substantial amount of conformal bone growth inside the implant socket, osseointegration. However, this conventional implant attachment does not include the periodontal ligament (PDL), which has a fundamental role in cushioning high mechanical loads. As a result, tooth implants have a shorter lifetime than the natural tooth and have a high chance of infections. We have engineered a “bio-implant” that provides a living PDL connection for titanium implants. The bio-implant consists of a hydroxyapatite coated titanium screw, ensheathed in cell sheets made from immortalized human periodontal cells. Bio-implants were transplanted into the upper first molar region of a tooth-extraction mouse model. Within 8 weeks the bio-implant generated fibrous connective tissue, a localised blood vessel network and new bone growth fused into the alveolar bone socket. The study presents a bio-implant engineered with human cells, specialised for the root connection, and resulted in the partial reconstruction of a naturalised tooth attachment complex (periodontium), consisting of all the principal tissue types, cementum, PDL and alveolar bone.Dong-Joon LeeJong-Min LeeEun-Jung KimTakashi TakataYoshihiro AbikoTeruo OkanoDavid W. GreenMasaki ShimonoHan-Sung JungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong-Joon Lee Jong-Min Lee Eun-Jung Kim Takashi Takata Yoshihiro Abiko Teruo Okano David W. Green Masaki Shimono Han-Sung Jung Bio-implant as a novel restoration for tooth loss
description	Abstract A dental implant is used to replace a missing tooth. Fixing the implant in its natural position requires the engineering of a substantial amount of conformal bone growth inside the implant socket, osseointegration. However, this conventional implant attachment does not include the periodontal ligament (PDL), which has a fundamental role in cushioning high mechanical loads. As a result, tooth implants have a shorter lifetime than the natural tooth and have a high chance of infections. We have engineered a “bio-implant” that provides a living PDL connection for titanium implants. The bio-implant consists of a hydroxyapatite coated titanium screw, ensheathed in cell sheets made from immortalized human periodontal cells. Bio-implants were transplanted into the upper first molar region of a tooth-extraction mouse model. Within 8 weeks the bio-implant generated fibrous connective tissue, a localised blood vessel network and new bone growth fused into the alveolar bone socket. The study presents a bio-implant engineered with human cells, specialised for the root connection, and resulted in the partial reconstruction of a naturalised tooth attachment complex (periodontium), consisting of all the principal tissue types, cementum, PDL and alveolar bone.
format	article
author	Dong-Joon Lee Jong-Min Lee Eun-Jung Kim Takashi Takata Yoshihiro Abiko Teruo Okano David W. Green Masaki Shimono Han-Sung Jung
author_facet	Dong-Joon Lee Jong-Min Lee Eun-Jung Kim Takashi Takata Yoshihiro Abiko Teruo Okano David W. Green Masaki Shimono Han-Sung Jung
author_sort	Dong-Joon Lee
title	Bio-implant as a novel restoration for tooth loss
title_short	Bio-implant as a novel restoration for tooth loss
title_full	Bio-implant as a novel restoration for tooth loss
title_fullStr	Bio-implant as a novel restoration for tooth loss
title_full_unstemmed	Bio-implant as a novel restoration for tooth loss
title_sort	bio-implant as a novel restoration for tooth loss
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7bd496afab284c61877c6ae73b08ca81
work_keys_str_mv	AT dongjoonlee bioimplantasanovelrestorationfortoothloss AT jongminlee bioimplantasanovelrestorationfortoothloss AT eunjungkim bioimplantasanovelrestorationfortoothloss AT takashitakata bioimplantasanovelrestorationfortoothloss AT yoshihiroabiko bioimplantasanovelrestorationfortoothloss AT teruookano bioimplantasanovelrestorationfortoothloss AT davidwgreen bioimplantasanovelrestorationfortoothloss AT masakishimono bioimplantasanovelrestorationfortoothloss AT hansungjung bioimplantasanovelrestorationfortoothloss
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Bio-implant as a novel restoration for tooth loss

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