MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.

Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented by the evolutionarily conserved major-histocompatibility-complex (MHC) class I molecule, MR1. Here we sh...

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Autores principales:	Lionel Le Bourhis, Mathilde Dusseaux, Armelle Bohineust, Stéphanie Bessoles, Emmanuel Martin, Virginie Premel, Maxime Coré, David Sleurs, Nacer-Eddine Serriari, Emmanuel Treiner, Claire Hivroz, Philippe Sansonetti, Marie-Lise Gougeon, Claire Soudais, Olivier Lantz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7bd53988a4ac4006b76003a1105be09d
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spelling	oai:doaj.org-article:7bd53988a4ac4006b76003a1105be09d2021-11-18T06:07:31ZMAIT cells detect and efficiently lyse bacterially-infected epithelial cells.1553-73661553-737410.1371/journal.ppat.1003681https://doaj.org/article/7bd53988a4ac4006b76003a1105be09d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24130485/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented by the evolutionarily conserved major-histocompatibility-complex (MHC) class I molecule, MR1. Here we show that MAIT cells display cytotoxic activity towards MR1 overexpressing non-hematopoietic cells cocultured with bacteria. The NK receptor, CD161, highly expressed by MAIT cells, modulated the cytokine but not the cytotoxic response triggered by bacteria infected cells. MAIT cells are also activated by and kill epithelial cells expressing endogenous levels of MRI after infection with the invasive bacteria Shigella flexneri. In contrast, MAIT cells were not activated by epithelial cells infected by Salmonella enterica Typhimurium. Finally, MAIT cells are activated in human volunteers receiving an attenuated strain of Shigella dysenteriae-1 tested as a potential vaccine. Thus, in humans, MAIT cells are the most abundant T cell subset able to detect and kill bacteria infected cells.Lionel Le BourhisMathilde DusseauxArmelle BohineustStéphanie BessolesEmmanuel MartinVirginie PremelMaxime CoréDavid SleursNacer-Eddine SerriariEmmanuel TreinerClaire HivrozPhilippe SansonettiMarie-Lise GougeonClaire SoudaisOlivier LantzPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 10, p e1003681 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Lionel Le Bourhis Mathilde Dusseaux Armelle Bohineust Stéphanie Bessoles Emmanuel Martin Virginie Premel Maxime Coré David Sleurs Nacer-Eddine Serriari Emmanuel Treiner Claire Hivroz Philippe Sansonetti Marie-Lise Gougeon Claire Soudais Olivier Lantz MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.
description	Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented by the evolutionarily conserved major-histocompatibility-complex (MHC) class I molecule, MR1. Here we show that MAIT cells display cytotoxic activity towards MR1 overexpressing non-hematopoietic cells cocultured with bacteria. The NK receptor, CD161, highly expressed by MAIT cells, modulated the cytokine but not the cytotoxic response triggered by bacteria infected cells. MAIT cells are also activated by and kill epithelial cells expressing endogenous levels of MRI after infection with the invasive bacteria Shigella flexneri. In contrast, MAIT cells were not activated by epithelial cells infected by Salmonella enterica Typhimurium. Finally, MAIT cells are activated in human volunteers receiving an attenuated strain of Shigella dysenteriae-1 tested as a potential vaccine. Thus, in humans, MAIT cells are the most abundant T cell subset able to detect and kill bacteria infected cells.
format	article
author	Lionel Le Bourhis Mathilde Dusseaux Armelle Bohineust Stéphanie Bessoles Emmanuel Martin Virginie Premel Maxime Coré David Sleurs Nacer-Eddine Serriari Emmanuel Treiner Claire Hivroz Philippe Sansonetti Marie-Lise Gougeon Claire Soudais Olivier Lantz
author_facet	Lionel Le Bourhis Mathilde Dusseaux Armelle Bohineust Stéphanie Bessoles Emmanuel Martin Virginie Premel Maxime Coré David Sleurs Nacer-Eddine Serriari Emmanuel Treiner Claire Hivroz Philippe Sansonetti Marie-Lise Gougeon Claire Soudais Olivier Lantz
author_sort	Lionel Le Bourhis
title	MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.
title_short	MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.
title_full	MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.
title_fullStr	MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.
title_full_unstemmed	MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.
title_sort	mait cells detect and efficiently lyse bacterially-infected epithelial cells.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7bd53988a4ac4006b76003a1105be09d
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MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.

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