Decreased mean platelet volume in panic disorder
Işil Göğçegöz Gül, Gül Eryilmaz, Eylem Özten, Gökben Hizli Sayar Neuropsychiatry Health, Practice, and Research Center, Uskudar University, Istanbul, Turkey Aim: The relationship between psychological stress and platelet ac...
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Dove Medical Press
2014
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oai:doaj.org-article:7bd5ff4342364fe095349d6873d59f922021-12-02T02:39:50ZDecreased mean platelet volume in panic disorder1178-2021https://doaj.org/article/7bd5ff4342364fe095349d6873d59f922014-09-01T00:00:00Zhttp://www.dovepress.com/decreased-mean-platelet-volume-in-panic-disorder-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Işil Göğçegöz Gül, Gül Eryilmaz, Eylem Özten, Gökben Hizli Sayar Neuropsychiatry Health, Practice, and Research Center, Uskudar University, Istanbul, Turkey Aim: The relationship between psychological stress and platelet activation has been widely studied. It is well known that platelets may reflect certain biochemical changes that occur in the brain when different mental conditions occur. Platelet 5-hydroxytryptamine (5-HT) is also extensively studied in psychiatry. The mean platelet volume (MPV), the accurate measure of platelet size, has been considered a marker and determinant of platelet function. The aim of the present study was to search for any probable difference in the MPV of subjects with panic disorder (PD).Methods: A total of 37 drug-free subjects, aged 18 to 65 years, diagnosed with PD, with or without agoraphobia, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth edition (DSM-IV) criteria and 45 healthy control subjects were included in the study. Platelet count and MPV were measured and recorded for each subject.Results: There were no statistically significant differences between groups in terms of female/male ratio, age, or body mass index between the PD group and control group (P=0.91, P=0.82, and P=0.93, respectively). The MPV was found to be significantly lower in the PD group compared with the control group (8.8±0.9 fL vs 9.2±0.8 fL; P=0.02). All the participants had MPV values in the standard range of 6.9–10.8 fL.Conclusion: We concluded that abnormalities of the 5-HT1A receptor function in the central nervous system of subjects with a diagnosis of PD are also mirrored in as an alteration in platelet activity. Measurements of platelet activity may be used as a tool for neuropsychiatric and psychopharmacological research and for studying how certain mental diseases and medications affect the central nervous system. Keywords: 5-HT, thrombocyte, anxiety Göğçegöz Gül IEryılmaz GÖzten EHızlı Sayar GDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1665-1669 (2014) |
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DOAJ |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Göğçegöz Gül I Eryılmaz G Özten E Hızlı Sayar G Decreased mean platelet volume in panic disorder |
| description |
Işil Göğçegöz Gül, Gül Eryilmaz, Eylem Özten, Gökben Hizli Sayar Neuropsychiatry Health, Practice, and Research Center, Uskudar University, Istanbul, Turkey Aim: The relationship between psychological stress and platelet activation has been widely studied. It is well known that platelets may reflect certain biochemical changes that occur in the brain when different mental conditions occur. Platelet 5-hydroxytryptamine (5-HT) is also extensively studied in psychiatry. The mean platelet volume (MPV), the accurate measure of platelet size, has been considered a marker and determinant of platelet function. The aim of the present study was to search for any probable difference in the MPV of subjects with panic disorder (PD).Methods: A total of 37 drug-free subjects, aged 18 to 65 years, diagnosed with PD, with or without agoraphobia, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth edition (DSM-IV) criteria and 45 healthy control subjects were included in the study. Platelet count and MPV were measured and recorded for each subject.Results: There were no statistically significant differences between groups in terms of female/male ratio, age, or body mass index between the PD group and control group (P=0.91, P=0.82, and P=0.93, respectively). The MPV was found to be significantly lower in the PD group compared with the control group (8.8±0.9 fL vs 9.2±0.8 fL; P=0.02). All the participants had MPV values in the standard range of 6.9–10.8 fL.Conclusion: We concluded that abnormalities of the 5-HT1A receptor function in the central nervous system of subjects with a diagnosis of PD are also mirrored in as an alteration in platelet activity. Measurements of platelet activity may be used as a tool for neuropsychiatric and psychopharmacological research and for studying how certain mental diseases and medications affect the central nervous system. Keywords: 5-HT, thrombocyte, anxiety |
| format |
article |
| author |
Göğçegöz Gül I Eryılmaz G Özten E Hızlı Sayar G |
| author_facet |
Göğçegöz Gül I Eryılmaz G Özten E Hızlı Sayar G |
| author_sort |
Göğçegöz Gül I |
| title |
Decreased mean platelet volume in panic disorder |
| title_short |
Decreased mean platelet volume in panic disorder |
| title_full |
Decreased mean platelet volume in panic disorder |
| title_fullStr |
Decreased mean platelet volume in panic disorder |
| title_full_unstemmed |
Decreased mean platelet volume in panic disorder |
| title_sort |
decreased mean platelet volume in panic disorder |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/7bd5ff4342364fe095349d6873d59f92 |
| work_keys_str_mv |
AT gogcegozguli decreasedmeanplateletvolumeinpanicdisorder AT eryılmazg decreasedmeanplateletvolumeinpanicdisorder AT oztene decreasedmeanplateletvolumeinpanicdisorder AT hızlısayarg decreasedmeanplateletvolumeinpanicdisorder |
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