DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation

Osteoclasts are involved in arthritis, and their differentiation depends on RANKL signaling. The author show that the ROS-scavenging protein DJ-1 negatively regulates RANKL signaling and that its ablation increases osteoclast numbers and exacerbates bone damage in mouse models of arthritis.

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Autores principales:	Hyuk Soon Kim, Seung Taek Nam, Se Hwan Mun, Sun-Kyeong Lee, Hyun Woo Kim, Young Hwan Park, Bokyung Kim, Kyung-Jong Won, Hae-Rim Kim, Yeong-Min Park, Hyung Sik Kim, Michael A. Beaven, Young Mi Kim, Wahn Soo Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7bd78c090e134d91823277ac336771c2
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spelling	oai:doaj.org-article:7bd78c090e134d91823277ac336771c22021-12-02T15:37:00ZDJ-1 controls bone homeostasis through the regulation of osteoclast differentiation10.1038/s41467-017-01527-y2041-1723https://doaj.org/article/7bd78c090e134d91823277ac336771c22017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01527-yhttps://doaj.org/toc/2041-1723Osteoclasts are involved in arthritis, and their differentiation depends on RANKL signaling. The author show that the ROS-scavenging protein DJ-1 negatively regulates RANKL signaling and that its ablation increases osteoclast numbers and exacerbates bone damage in mouse models of arthritis.Hyuk Soon KimSeung Taek NamSe Hwan MunSun-Kyeong LeeHyun Woo KimYoung Hwan ParkBokyung KimKyung-Jong WonHae-Rim KimYeong-Min ParkHyung Sik KimMichael A. BeavenYoung Mi KimWahn Soo ChoiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyuk Soon Kim Seung Taek Nam Se Hwan Mun Sun-Kyeong Lee Hyun Woo Kim Young Hwan Park Bokyung Kim Kyung-Jong Won Hae-Rim Kim Yeong-Min Park Hyung Sik Kim Michael A. Beaven Young Mi Kim Wahn Soo Choi DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation
description	Osteoclasts are involved in arthritis, and their differentiation depends on RANKL signaling. The author show that the ROS-scavenging protein DJ-1 negatively regulates RANKL signaling and that its ablation increases osteoclast numbers and exacerbates bone damage in mouse models of arthritis.
format	article
author	Hyuk Soon Kim Seung Taek Nam Se Hwan Mun Sun-Kyeong Lee Hyun Woo Kim Young Hwan Park Bokyung Kim Kyung-Jong Won Hae-Rim Kim Yeong-Min Park Hyung Sik Kim Michael A. Beaven Young Mi Kim Wahn Soo Choi
author_facet	Hyuk Soon Kim Seung Taek Nam Se Hwan Mun Sun-Kyeong Lee Hyun Woo Kim Young Hwan Park Bokyung Kim Kyung-Jong Won Hae-Rim Kim Yeong-Min Park Hyung Sik Kim Michael A. Beaven Young Mi Kim Wahn Soo Choi
author_sort	Hyuk Soon Kim
title	DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation
title_short	DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation
title_full	DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation
title_fullStr	DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation
title_full_unstemmed	DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation
title_sort	dj-1 controls bone homeostasis through the regulation of osteoclast differentiation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7bd78c090e134d91823277ac336771c2
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_version_	1718386298052411392

DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation

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