Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls

Abstract Microcirculatory dysfunction occurs early in cardiovascular disease (CVD) development. Acute myocardial infarction (MI) is a late consequence of CVD. The conjunctival microcirculation is readily-accessible for quantitative assessment and has not previously been studied in MI patients. We co...

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Autores principales:	Paul F. Brennan, Andrew J. McNeil, Min Jing, Agnes Awuah, Julie S. Moore, Jonathan Mailey, Dewar D. Finlay, Kevin Blighe, James A. D. McLaughlin, M. Andrew Nesbit, Emanuele Trucco, Tara C. B. Moore, Mark S. Spence
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7bdaf552c0254baabcc6ae23f557d2a2
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spelling	oai:doaj.org-article:7bdaf552c0254baabcc6ae23f557d2a22021-12-02T18:15:25ZAssessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls10.1038/s41598-021-87315-72045-2322https://doaj.org/article/7bdaf552c0254baabcc6ae23f557d2a22021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87315-7https://doaj.org/toc/2045-2322Abstract Microcirculatory dysfunction occurs early in cardiovascular disease (CVD) development. Acute myocardial infarction (MI) is a late consequence of CVD. The conjunctival microcirculation is readily-accessible for quantitative assessment and has not previously been studied in MI patients. We compared the conjunctival microcirculation of acute MI patients and age/sex-matched healthy controls to determine if there were differences in microcirculatory parameters. We acquired images using an iPhone 6s and slit-lamp biomicroscope. Parameters measured included diameter, axial velocity, wall shear rate and blood volume flow. Results are for all vessels as they were not sub-classified into arterioles or venules. The conjunctival microcirculation was assessed in 56 controls and 59 inpatients with a presenting diagnosis of MI. Mean vessel diameter for the controls was 21.41 ± 7.57 μm compared to 22.32 ± 7.66 μm for the MI patients (p < 0.001). Axial velocity for the controls was 0.53 ± 0.15 mm/s compared to 0.49 ± 0.17 mm/s for the MI patients (p < 0.001). Wall shear rate was higher for controls than MI patients (162 ± 93 s−1 vs 145 ± 88 s−1, p < 0.001). Blood volume flow did not differ significantly for the controls and MI patients (153 ± 124 pl/s vs 154 ± 125 pl/s, p = 0.84). This pilot iPhone and slit-lamp assessment of the conjunctival microcirculation found lower axial velocity and wall shear rate in patients with acute MI. Further study is required to correlate these findings further and assess long-term outcomes in this patient group with a severe CVD phenotype.Paul F. BrennanAndrew J. McNeilMin JingAgnes AwuahJulie S. MooreJonathan MaileyDewar D. FinlayKevin BligheJames A. D. McLaughlinM. Andrew NesbitEmanuele TruccoTara C. B. MooreMark S. SpenceNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paul F. Brennan Andrew J. McNeil Min Jing Agnes Awuah Julie S. Moore Jonathan Mailey Dewar D. Finlay Kevin Blighe James A. D. McLaughlin M. Andrew Nesbit Emanuele Trucco Tara C. B. Moore Mark S. Spence Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls
description	Abstract Microcirculatory dysfunction occurs early in cardiovascular disease (CVD) development. Acute myocardial infarction (MI) is a late consequence of CVD. The conjunctival microcirculation is readily-accessible for quantitative assessment and has not previously been studied in MI patients. We compared the conjunctival microcirculation of acute MI patients and age/sex-matched healthy controls to determine if there were differences in microcirculatory parameters. We acquired images using an iPhone 6s and slit-lamp biomicroscope. Parameters measured included diameter, axial velocity, wall shear rate and blood volume flow. Results are for all vessels as they were not sub-classified into arterioles or venules. The conjunctival microcirculation was assessed in 56 controls and 59 inpatients with a presenting diagnosis of MI. Mean vessel diameter for the controls was 21.41 ± 7.57 μm compared to 22.32 ± 7.66 μm for the MI patients (p < 0.001). Axial velocity for the controls was 0.53 ± 0.15 mm/s compared to 0.49 ± 0.17 mm/s for the MI patients (p < 0.001). Wall shear rate was higher for controls than MI patients (162 ± 93 s−1 vs 145 ± 88 s−1, p < 0.001). Blood volume flow did not differ significantly for the controls and MI patients (153 ± 124 pl/s vs 154 ± 125 pl/s, p = 0.84). This pilot iPhone and slit-lamp assessment of the conjunctival microcirculation found lower axial velocity and wall shear rate in patients with acute MI. Further study is required to correlate these findings further and assess long-term outcomes in this patient group with a severe CVD phenotype.
format	article
author	Paul F. Brennan Andrew J. McNeil Min Jing Agnes Awuah Julie S. Moore Jonathan Mailey Dewar D. Finlay Kevin Blighe James A. D. McLaughlin M. Andrew Nesbit Emanuele Trucco Tara C. B. Moore Mark S. Spence
author_facet	Paul F. Brennan Andrew J. McNeil Min Jing Agnes Awuah Julie S. Moore Jonathan Mailey Dewar D. Finlay Kevin Blighe James A. D. McLaughlin M. Andrew Nesbit Emanuele Trucco Tara C. B. Moore Mark S. Spence
author_sort	Paul F. Brennan
title	Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls
title_short	Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls
title_full	Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls
title_fullStr	Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls
title_full_unstemmed	Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls
title_sort	assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7bdaf552c0254baabcc6ae23f557d2a2
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Assessment of the conjunctival microcirculation for patients presenting with acute myocardial infarction compared to healthy controls

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