Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

Differentially methylated CpGs can inform on disease mechanisms and be useful as biomarkers. Here, the authors perform GWAS for DNA methylation in whole blood, cis- and trans-meQTL mapping, followed by Mendelian randomization analysis that links meQTLs with cardiovascular diseases.

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Autores principales: Tianxiao Huan, Roby Joehanes, Ci Song, Fen Peng, Yichen Guo, Michael Mendelson, Chen Yao, Chunyu Liu, Jiantao Ma, Melissa Richard, Golareh Agha, Weihua Guan, Lynn M. Almli, Karen N. Conneely, Joshua Keefe, Shih-Jen Hwang, Andrew D. Johnson, Myriam Fornage, Liming Liang, Daniel Levy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7bdd0cfeebb44d3cb05a48f945dae102
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spelling oai:doaj.org-article:7bdd0cfeebb44d3cb05a48f945dae1022021-12-02T16:58:12ZGenome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease10.1038/s41467-019-12228-z2041-1723https://doaj.org/article/7bdd0cfeebb44d3cb05a48f945dae1022019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12228-zhttps://doaj.org/toc/2041-1723Differentially methylated CpGs can inform on disease mechanisms and be useful as biomarkers. Here, the authors perform GWAS for DNA methylation in whole blood, cis- and trans-meQTL mapping, followed by Mendelian randomization analysis that links meQTLs with cardiovascular diseases.Tianxiao HuanRoby JoehanesCi SongFen PengYichen GuoMichael MendelsonChen YaoChunyu LiuJiantao MaMelissa RichardGolareh AghaWeihua GuanLynn M. AlmliKaren N. ConneelyJoshua KeefeShih-Jen HwangAndrew D. JohnsonMyriam FornageLiming LiangDaniel LevyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tianxiao Huan
Roby Joehanes
Ci Song
Fen Peng
Yichen Guo
Michael Mendelson
Chen Yao
Chunyu Liu
Jiantao Ma
Melissa Richard
Golareh Agha
Weihua Guan
Lynn M. Almli
Karen N. Conneely
Joshua Keefe
Shih-Jen Hwang
Andrew D. Johnson
Myriam Fornage
Liming Liang
Daniel Levy
Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
description Differentially methylated CpGs can inform on disease mechanisms and be useful as biomarkers. Here, the authors perform GWAS for DNA methylation in whole blood, cis- and trans-meQTL mapping, followed by Mendelian randomization analysis that links meQTLs with cardiovascular diseases.
format article
author Tianxiao Huan
Roby Joehanes
Ci Song
Fen Peng
Yichen Guo
Michael Mendelson
Chen Yao
Chunyu Liu
Jiantao Ma
Melissa Richard
Golareh Agha
Weihua Guan
Lynn M. Almli
Karen N. Conneely
Joshua Keefe
Shih-Jen Hwang
Andrew D. Johnson
Myriam Fornage
Liming Liang
Daniel Levy
author_facet Tianxiao Huan
Roby Joehanes
Ci Song
Fen Peng
Yichen Guo
Michael Mendelson
Chen Yao
Chunyu Liu
Jiantao Ma
Melissa Richard
Golareh Agha
Weihua Guan
Lynn M. Almli
Karen N. Conneely
Joshua Keefe
Shih-Jen Hwang
Andrew D. Johnson
Myriam Fornage
Liming Liang
Daniel Levy
author_sort Tianxiao Huan
title Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
title_short Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
title_full Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
title_fullStr Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
title_full_unstemmed Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
title_sort genome-wide identification of dna methylation qtls in whole blood highlights pathways for cardiovascular disease
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/7bdd0cfeebb44d3cb05a48f945dae102
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