Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease

Differentially methylated CpGs can inform on disease mechanisms and be useful as biomarkers. Here, the authors perform GWAS for DNA methylation in whole blood, cis- and trans-meQTL mapping, followed by Mendelian randomization analysis that links meQTLs with cardiovascular diseases.

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Detalles Bibliográficos
Autores principales: Tianxiao Huan, Roby Joehanes, Ci Song, Fen Peng, Yichen Guo, Michael Mendelson, Chen Yao, Chunyu Liu, Jiantao Ma, Melissa Richard, Golareh Agha, Weihua Guan, Lynn M. Almli, Karen N. Conneely, Joshua Keefe, Shih-Jen Hwang, Andrew D. Johnson, Myriam Fornage, Liming Liang, Daniel Levy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/7bdd0cfeebb44d3cb05a48f945dae102
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