Cortical gyrification in schizophrenia: current perspectives

Yukihisa Matsuda,1 Kazutaka Ohi2,3 1Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan; 2Department of Neuropsychiatry, Kanazawa Medical University, Ishikawa, Japan; 3Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan Abstract: The cerebral...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matsuda Y, Ohi K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	schizophrenia cortical gyrification gyrification index Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7be2298429894fc398ff7a5bdca2b1ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7be2298429894fc398ff7a5bdca2b1ed
record_format	dspace
spelling	oai:doaj.org-article:7be2298429894fc398ff7a5bdca2b1ed2021-12-02T04:28:36ZCortical gyrification in schizophrenia: current perspectives1178-2021https://doaj.org/article/7be2298429894fc398ff7a5bdca2b1ed2018-07-01T00:00:00Zhttps://www.dovepress.com/cortical-gyrification-in-schizophrenia-current-perspectives-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yukihisa Matsuda,1 Kazutaka Ohi2,3 1Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan; 2Department of Neuropsychiatry, Kanazawa Medical University, Ishikawa, Japan; 3Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan Abstract: The cerebral cortex of the human brain has a complex morphological structure consisting of folded or smooth cortical surfaces. These morphological features are referred to as cortical gyrification and are characterized by the gyrification index (GI). A number of cortical gyrification studies have been published using the manual tracing GI, automated GI, and local GI in patients with schizophrenia. In this review, we highlighted abnormal cortical gyrification in patients with schizophrenia, first-episode schizophrenia, siblings of patients, and high-risk and at-risk individuals. Previous researches also indicated that abnormalities in cortical gyrification may underlie the severity of clinical symptoms, neurological soft signs, and executive functions. A substantial body of research has been conducted; however, some researches showed an increased GI, which is called as “hypergyria,” and others showed a decreased GI, which is called as “hypogyria.” We discussed that different GI methods and a wide variety of characteristics, such as age, sex, stage, and severity of illness, might be important reasons for the conflicting findings. These issues still need to be considered, and future studies should address them. Keywords: schizophrenia, cortical gyrification, gyrification indexMatsuda YOhi KDove Medical Pressarticleschizophreniacortical gyrificationgyrification indexNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1861-1869 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia cortical gyrification gyrification index Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	schizophrenia cortical gyrification gyrification index Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Matsuda Y Ohi K Cortical gyrification in schizophrenia: current perspectives
description	Yukihisa Matsuda,1 Kazutaka Ohi2,3 1Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan; 2Department of Neuropsychiatry, Kanazawa Medical University, Ishikawa, Japan; 3Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan Abstract: The cerebral cortex of the human brain has a complex morphological structure consisting of folded or smooth cortical surfaces. These morphological features are referred to as cortical gyrification and are characterized by the gyrification index (GI). A number of cortical gyrification studies have been published using the manual tracing GI, automated GI, and local GI in patients with schizophrenia. In this review, we highlighted abnormal cortical gyrification in patients with schizophrenia, first-episode schizophrenia, siblings of patients, and high-risk and at-risk individuals. Previous researches also indicated that abnormalities in cortical gyrification may underlie the severity of clinical symptoms, neurological soft signs, and executive functions. A substantial body of research has been conducted; however, some researches showed an increased GI, which is called as “hypergyria,” and others showed a decreased GI, which is called as “hypogyria.” We discussed that different GI methods and a wide variety of characteristics, such as age, sex, stage, and severity of illness, might be important reasons for the conflicting findings. These issues still need to be considered, and future studies should address them. Keywords: schizophrenia, cortical gyrification, gyrification index
format	article
author	Matsuda Y Ohi K
author_facet	Matsuda Y Ohi K
author_sort	Matsuda Y
title	Cortical gyrification in schizophrenia: current perspectives
title_short	Cortical gyrification in schizophrenia: current perspectives
title_full	Cortical gyrification in schizophrenia: current perspectives
title_fullStr	Cortical gyrification in schizophrenia: current perspectives
title_full_unstemmed	Cortical gyrification in schizophrenia: current perspectives
title_sort	cortical gyrification in schizophrenia: current perspectives
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/7be2298429894fc398ff7a5bdca2b1ed
work_keys_str_mv	AT matsuday corticalgyrificationinschizophreniacurrentperspectives AT ohik corticalgyrificationinschizophreniacurrentperspectives
_version_	1718401194964025344

Cortical gyrification in schizophrenia: current perspectives

Ejemplares similares