Atomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents

Fan Yang, Run Chang, Thomas J Webster Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USACorrespondence: Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, 313 Snell Engineering Center, 360 Huntington Avenue, Boston, MA 02115, USATel +1 617 37...

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Autores principales:	Yang F, Chang R, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	atomic layer deposition titanium dioxide magnesium bioresorbable vascular scaffold endothelium cytocompatibility Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7be80b84cbe04ccdbf393b679d0df9d9
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spelling	oai:doaj.org-article:7be80b84cbe04ccdbf393b679d0df9d92021-12-02T12:02:14ZAtomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents1178-2013https://doaj.org/article/7be80b84cbe04ccdbf393b679d0df9d92019-12-01T00:00:00Zhttps://www.dovepress.com/atomic-layer-deposition-coating-of-tio2-nano-thin-films-on-magnesium-z-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fan Yang, Run Chang, Thomas J Webster Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USACorrespondence: Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, 313 Snell Engineering Center, 360 Huntington Avenue, Boston, MA 02115, USATel +1 617 373 6585Email th.webster@neu.eduBackground and purpose: A coronary stent is a well-known cardiovascular medical device implanted to resolve disorders of the circulatory system due to bloodstream narrowing. Since the implanted device interacts with surrounding biological environments, the surface properties of a typical implantable stent play a critical role in its success or failure. Endothelial cell adhesion and proliferation are fundamental criteria needed for the success of a medical device. Metallic coronary stents are commonly used as biomaterial platforms in cardiovascular implants. As a new generation of coronary stents, bioresorbable vascular scaffolds have attracted a great deal of attention among researchers and studies on bioresorbable materials (such as magnesium and zinc) remain a target for further optimization. However, additional surface modification is needed to control the biodegradation of the implant material while promoting biological reactions without the use of drug elution.Methods: Herein, precise temperature and thickness controlled atomic layer deposition (ALD) was utilized to provide a unique and conformal nanoscale TiO2 coating on a customized magnesium-zinc stent alloy.Results: Impressively, results indicated that this TiO2 nano-thin film coating stimulated coronary arterial endothelial cell adhesion and proliferation with additional features acting as a protective barrier. Data revealed that both surface morphology and surface hydrophilicity contributed to the success of the ALD nanoscale coating, which further acted as a protection layer inhibiting the release of harmful degradation products from the magnesium-zinc stent.Conclusion: Overall, the outcome of this in vitro study provided a promising ALD stent coating with unique nano-structural surface properties for increased endothelialization, and as a result, ALD should be further studied for numerous biomedical applications.Keywords: atomic layer deposition, titanium dioxide, magnesium, bioresorbable vascular scaffold, endothelium, cytocompatibilityYang FChang RWebster TJDove Medical Pressarticleatomic layer depositiontitanium dioxidemagnesiumbioresorbable vascular scaffoldendotheliumcytocompatibilityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 9955-9970 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	atomic layer deposition titanium dioxide magnesium bioresorbable vascular scaffold endothelium cytocompatibility Medicine (General) R5-920
spellingShingle	atomic layer deposition titanium dioxide magnesium bioresorbable vascular scaffold endothelium cytocompatibility Medicine (General) R5-920 Yang F Chang R Webster TJ Atomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents
description	Fan Yang, Run Chang, Thomas J Webster Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USACorrespondence: Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, 313 Snell Engineering Center, 360 Huntington Avenue, Boston, MA 02115, USATel +1 617 373 6585Email th.webster@neu.eduBackground and purpose: A coronary stent is a well-known cardiovascular medical device implanted to resolve disorders of the circulatory system due to bloodstream narrowing. Since the implanted device interacts with surrounding biological environments, the surface properties of a typical implantable stent play a critical role in its success or failure. Endothelial cell adhesion and proliferation are fundamental criteria needed for the success of a medical device. Metallic coronary stents are commonly used as biomaterial platforms in cardiovascular implants. As a new generation of coronary stents, bioresorbable vascular scaffolds have attracted a great deal of attention among researchers and studies on bioresorbable materials (such as magnesium and zinc) remain a target for further optimization. However, additional surface modification is needed to control the biodegradation of the implant material while promoting biological reactions without the use of drug elution.Methods: Herein, precise temperature and thickness controlled atomic layer deposition (ALD) was utilized to provide a unique and conformal nanoscale TiO2 coating on a customized magnesium-zinc stent alloy.Results: Impressively, results indicated that this TiO2 nano-thin film coating stimulated coronary arterial endothelial cell adhesion and proliferation with additional features acting as a protective barrier. Data revealed that both surface morphology and surface hydrophilicity contributed to the success of the ALD nanoscale coating, which further acted as a protection layer inhibiting the release of harmful degradation products from the magnesium-zinc stent.Conclusion: Overall, the outcome of this in vitro study provided a promising ALD stent coating with unique nano-structural surface properties for increased endothelialization, and as a result, ALD should be further studied for numerous biomedical applications.Keywords: atomic layer deposition, titanium dioxide, magnesium, bioresorbable vascular scaffold, endothelium, cytocompatibility
format	article
author	Yang F Chang R Webster TJ
author_facet	Yang F Chang R Webster TJ
author_sort	Yang F
title	Atomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents
title_short	Atomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents
title_full	Atomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents
title_fullStr	Atomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents
title_full_unstemmed	Atomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents
title_sort	atomic layer deposition coating of tio2 nano-thin films on magnesium-zinc alloys to enhance cytocompatibility for bioresorbable vascular stents
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7be80b84cbe04ccdbf393b679d0df9d9
work_keys_str_mv	AT yangf atomiclayerdepositioncoatingoftio2nanothinfilmsonmagnesiumzincalloystoenhancecytocompatibilityforbioresorbablevascularstents AT changr atomiclayerdepositioncoatingoftio2nanothinfilmsonmagnesiumzincalloystoenhancecytocompatibilityforbioresorbablevascularstents AT webstertj atomiclayerdepositioncoatingoftio2nanothinfilmsonmagnesiumzincalloystoenhancecytocompatibilityforbioresorbablevascularstents
_version_	1718394757381619712

Atomic Layer Deposition Coating of TiO2 Nano-Thin Films on Magnesium-Zinc Alloys to Enhance Cytocompatibility for Bioresorbable Vascular Stents

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